Université´ D'aix-marseille

Centre National De La Recherche Scientifique

Commissariat a L'energie Atomique

Francois Le Moigne

Paul Tordo

Hakim Karoui

Yoh Matsuki

Robert G Griffin

Thorsten Maly

Nelly Kernevez

Olivier Ouari

Sylvia Pietri

Oliver Ouari

Marcel Culcasi

Liliane Secourgeon

Yves Berchadsky

Anne Mercier

Claudine Marie Barbe Frejaville

The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which involves transferring the polarization of electron spins to the nuclei of a compound whose Nuclear Magnetic Resonance (NMR) is being observed. It concerns Dinitroxide-type Biradical polarizing agents characterized by a rigid linkage between the aminoxyl groups of said nitroxide units. This particular structure enables, at low temperatures and high fields, optimal transfer of polarization and optimal enhancement of NMR/MAS signals of the polarized nuclei of the compound studied.

Dinitroxide-type biradical compounds optimized for dynamic nuclear polarization (DNP)

The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which involves transferring the polarization of electron spins to the nuclei of a compound whose Nuclear Magnetic Resonance (NMR) is being observed. It concerns dinitroxide-type biradical polarizing agents characterized by a rigid linkage between the nitroxide units that enables optimal orientation and distance to be maintained between the aminoxyl groups of said nitroxide units. This particular structure enables, at low temperatures and high fields, optimal transfer of polarization and optimal enhancement of NMR/MAS signals of the polarized nuclei of the compound studied.

Nitrones which are usable for the scavenging of free radicals

A nitroxide radical of the formula (I) or (II): ##STR1## in which R.sub.1 and R.sub.2 are independently chosen from among the optionally deuterated alkyl, alkoxyl, dialkylaminyl and phenyl radicals, H, D or Cl; R.sub.3, R.sub.8 and R.sub.9 are independently chosen from among the optionally deuterated alkyl, alkoxyl and phenyl radicals; R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are independently chosen from among the optionally deuterated alkyl, alkoxyl, dialkylaminyl and phenyl radicals, COOH, OH, OD, H, D, a halogen, COOR (in which R is an alkyl radical); R.sub.10 and R.sub.11 are independently chosen from among optionally deuterated alkyl, alkoxyl, dialkylaminyl and phenyl radicals, COOH, OH, OD, H, D, a halogen, COOR (in which R is an alkyl radical) or represent an oxygen atom linked with the cycle of the radical by a double bond is described.

Phosphorus-containing cyclic nitroxide free radicals

Growing community of inventors

Tredrez Locquemeau, France

Francois Le Moigne