Institut National De La Sante Et De La Recherche Medicale

Centre National De La Recherche Scientifique

Université D'angers

Francois Lang

Nathalie Labarriere

Marc Bonneville

Mathilde Bobinet

Anne Rogel

Karine Bernardeau

Regis Bouquie

Marie Bodinier

Francois Davodeau

The present invention relates to a melanoma antigen peptide comprising the amino acids sequence selected in the group consisting of SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14 or SEQ ID NO: 15 or a function-conservative variant thereof. Moreover the invention also relates to a melanoma antigen peptide according to the invention for use in the prevention or the treatment of melanoma in patient.

Melanoma antigen peptide and uses thereof

The application relates to antibodies which recognize the AviTag&#x2122; peptide of sequence MSGLNDIFEAQKIEWHE (SEQ ID No. 1) and to fragments thereof which recognize SEQ ID No. 1, wherein said antibodies or said fragments thereof recognize polypeptides containing SEQ ID No. 1 at their NH2 terminus and polypeptides containing SEQ ID No. 1 at their COOH terminus. The application further relates to a method for sorting target cells presenting on their surface a surface marker from a mixed cell population comprising the steps of: a) incubating said mixed cell population with a tagged adapter which binds to said surface marker of said target cells, wherein said adapter is bound to an antibody which recognizes said tag, and wherein said antibody is immobilized on a solid support. b) collecting said target cells.

Antibody or fragment thereof recognizing Avitag&#x2122; and uses thereof

The invention concerns multimers developed from recombinant proteins analogues of MHC class I.

Means for detection and purification of CD8+  T lymphocyte populations specific to peptides presented in the context of HLA

Growing community of inventors

Nantes, France

Francois Lang