Pherecydes Pharma

Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Bio Modeling Systems Ou Bmsystems

François Iris

Flavie Pouillot

Jean-Philippe Deslys

Franck Mouthon

Mathieu Charveriat

The invention first relates to a product containing at least one connexin-blocking agent and a psychotropic drug as combination products for use simultaneously, separately, or spread over time in patients suffering from psychiatric and/or neurodegenerative disorders. The connexin-blocking agent is advantageously selected from the group comprising meclofenamic acid, 18-&#x3b2;-glycyrrhetinic acid, carbenoxolone, mefloquine, and 2-APB, and preferably consists of meclofenamic acid. The invention first relates to a product containing at least one connexin-blocking agent and a psychotropic drug as combination products for use simultaneously, separately, or spread over time in patients suffering from psychiatric and/or neurodegenerative disorders. The connexin-blocking agent is advantageously selected from the group comprising meclofenamic acid, 18-&#x3b2;-glycyrrhetinic acid, carbenoxolone, mefloquine, and 2-APB, and preferably consists of meclofenamic acid.

Use of anti-connexin agents for modulating the therapeutic effect of psychotropic drugs

The invention relates to a method for obtaining a variety of recombinant bacteriophages in which the screening proteins have been modified by the insertion in their genetic sequence of randomly produced oligonucleotides, and to bacteriophages banks that can be obtained according to said method.

Method for the preparation of modified bacteriophages by insertion of random sequences in the targeting proteins of said bacteriophages

The present invention relates to a method for the reversible immobilization of lytic bacteriophages within their modified bacterial hosts. It relates more particularly to a method for modifying the genome of a lytic bacteriophage by immobilizing said bacteriophage in the host bacterium thereof.

Modification of the genome of a lytic bacteriophage by immobilizing said bacteriophage in the host bacterium thereof

The invention relates to a very general method for the random diversification of a nucleotide sequence S by PCR while preserving the identity of some domains of said sequence S; the invention also relates to a bank of nucleotide sequence thus diversified, and to diversified proteins obtained by the expressions of the nucleotide sequences in an appropriate host.

Growing community of inventors

Chaville, France

François Iris