University System of Maryland

Francois Germain Noel

Edson X Albuquerque

Roberto Takashi Sudo

Patricia Dias Fernandes

Paulo De Assis Melo

Ana Luisa Palhares De Miranda

Newton Goncalves De Castro

Wagner Monteiro Cintra

Carlos Alberto Manssour Fraga

Eliezer J De Barreiro

Gisele Zapata Sudo

Yasco Aracava

Claudia Lucia Martins Da Silva

The invention discloses a compound having the formula (I) wherein Ris selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, unsubstituted phenyl, and substituted phenyl; Ris selected from the group consisting of H, alkene, un-substituted phenol, and substituted phenyl; and pharmaceutically acceptable salts thereof, having digitalis-like properties. The invention further discloses a novel method to synthesize 3,4-methylenedioxybenzoyl-2-thienylhydrazone (LASSBio-294). LASSBio-294 produces positive inotropic effect on cardiac and skeletal muscle. The invention is useful for the treatment of congestive heart failure and muscle fatigue. It lacks toxic effects seen in digitalis glycosides.

Thienylhydrazon with digitalis-like properties (positive inotropic effects)

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Rio de Janeiro, Brazil

Francois Germain Noel