Sanofi Pasteur Sa

Sanofi Pasteur Inc.

Francois Dalencon

Jean Haensler

Scott Gallichan

Patricia Probeck-Quellec

Ausra Mancevski

Nathalie Reveneau

Jin Su

The present invention provides compositions comprising a Chlamydial major outer membrane protein (referenced herein as 'MOMP'), from at least one Chlamydial serovar and an adjuvant, characterized in that the adjuvant comprises the product E6020 having CAS Number 287180-63-6. The composition may further comprise at least one carrier system (e.g., emulsion, mineral particle). The MOMP protein may be derived from any species of(e.g.,, orMoPn). In preferred embodiments, the composition comprises one or more major outer membrane proteins each derived from different serovars of. The invention also provides methods of inducing an immune response to aspecies (e.g.,) in a subject, by administering to the subject a composition of the invention.

Immunogenic compositions

The invention relates to an oil-in-water adjuvant emulsion which comprises at least: The invention also relates to a process for preparing an immunogenic composition according to which at least one vaccine antigen is mixed with an oil-in-water emulsion, wherein the oil-in-water emulsion is obtained by means of a temperature-variation phase-inversion process.

Immuno-adjuvant emulsion

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Lyons, France

Francois Dalencon