Lipha, Lyonnaise Industrielle Pharmaceutique

Merck Patent Gmbh

Merck Patent Gesellschaft MIT Beschrankter Haftung

Merck Patent Gesellschaft MIT

Francois Collonges

Claude Lardy

Herve Dumas

Daniel Guerrier

Jean-Jacques Berthelon

Philippe Briet

Philippe Durbin

Jaques Barbanton

Gilles Chavernac

Hervé Dumas

Peter Kane

Philippe Guedat

Stéphane Yvon

Jacques Decerprit

Olivier Chevreuil

Philippe Guèdat

Robert J Foster

Bernd Went

Julia Lainton

Avril Robertson

Bernd Wendt

Phillippe Durbin

Jean-Yves Ortholand

Marie Noelle Denault

Jaxques Barbanton

The present invention relates to derivatives of aroyl-O-piperidine structure of the general formula (I): in which R, R, Rand Rare as defined in the description. Application of the compounds of the formula (I) to the treatment of hyper-triglyceridaemia, hypercholesterolaemia and dyslipidaemia, and to the prevention or treatment of obesity. 

Aroyl-O-piperidine derivatives for the treatment of diabetes-related problems

The present invention relates to thiazolylpiperidine derivatives of the general formula (I):    Application of the compounds of the formula (I) to the treatment of hypertriglyceridaemia, hypercholesterolaemia and dyslipidaemia.

Thiazolypiperidine derivatives as MTP inhibitors

Nitromethyl ketone compounds having aldose reduction inhibiting properties and methods for their use

The present invention relates to the compounds of formula: ##STR1## in which R.sub.1, R.sub.2, R.sub.3, E, A, X, Z, p and n are as defined herein. These compounds are aldose reductase inhibitors.

Nitromethyl ketones, process for preparing them and compositions

3,4-dihydro-4-oxo-3-(2-propenyl)-1-phthalazineacetic acids and

The present invention concerns new substituted sulfonamides, and the physiologically acceptable salts, complexes, esters and amides thereof, represented by the formula ##STR1## which is defined herein. Said compounds find application as anti-thrombotic and anti-asthmatic medicines.

Substituted sulfonamides, process of preparation and medicines

The present invention concerns new substituted sulfonamides, and the physiologically acceptable salts possibly in the form of complexes, esters and amides thereof, represented by the formula: ##STR1##

Substituted six-membered benzo-fused heterocycles of the formula (I) ##STR1## in which: X=0, NH, S.fwdarw.(O).sub.n (n=0 or 2);

Pharmaceutically useful flavonoic compounds containing at least one

The invention concerns [oxo-4-4H-[1]-benzopyran-8-yl]-alcanoic acids and their derivatives, their manufacture, represented by the formula. ##STR1## where AR is hydrogen, a phenyl radical which may or may not be substituted thenyl, furyl, naphthyl, a lower alkyl, cycloalkyl, aralkyl radical; B is a linear or branched lower alkyl radical, either saturated or ethylinically unsaturated; R.sub.1 is hydrogen or a phenyl radical; X is hydrogen or a lower alkyl or alkoxy radical and n=1, as well as salts, esters, aminoesters and amides. Compounds and their derivatives may be used as medicines, in particular in the control of tumors.

[Oxo-4-4H-[1]-benzopyran-8-yl]alcanoic acids, salts and derivatives,

The invention concerns: (oxo-4-4H-(1)-benzopyran-8-yl) alkanoic acids and their derivatives, their manufacture, represented by the formula: ##STR1## where Ar is hydrogen, a phenyl radical which may or may not be substituted, thenyl, furyl, naphthyl, a lower alkyl, cycloalkyl, aralkyl radical; B is a linear or branched lower alkyl radical, either saturated or ethylinically unsaturated; R.sub.1 is hydrogen or a phenyl radical; X is hydrogen or a lower alkyl or alkoxy radical and n=1, as well as salts, esters, aminoesters and amides. Compounds and their derivatives may be used as medicines, in particular in the control of tumors.

(Oxo-4-4H-(1)-benzopyran-8-yl) alkanoic acids, salts and derivatives,

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Beynost, France

Francois Collonges