Fournier Innovation Et Synergie

Fournier Industrie Et Sante

Centre National De La Recherche Scientifique

Université De Nantes

Université Clermont Auvergne

Societe De Recherches Industrielles Sori

Enterome

Institut De Recherches Chimiques Et Al

Societe De Recheres Industrielles

Societe De Recherches Industries (s.o.r.i.)

Societe De Recherches Industrielle S.o.r.i.

Nantes Université

Francois Bellamy

Soth Samreth

Jean Millet

Jacques Robin

Alain Moussy

Patrice Renaut

Bernard Majoie

Didier Pruneau

Veronique Barberousse

Pierre Dodey

Philippe Reginault

Anne Lermet

Sebastien Gouin

Adeline Sivignon

Julie Bouckaert

Dimitri Alvarez-Dorta

Jerzy Bajgrowicz

Bernard Rasquin

Nicolas Barnich

Thibault Chalopin

Jean-Bernard Chazan

Dimitri Alexander Alvarez-Dorta

The present invention relates to mannose derivatives of formula (I): wherein The mannose derivatives of formulae (I) are useful for treating pathologies associated with the presence of adherent(AEC), in particular inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis; a urinary tract infection, in particular painful bladder syndrome and cystitis, more particularly interstitial cystitis; irritable bowel syndrome; metabolic diseases such as metabolic obesity, diabetes, hypercholesterolemia; autoimmune inflammatory diseases; and colorectal cancer, in particular colon cancer.

Mannose derivatives useful for treating pathologies associated with adherent

This invention is concerned with a novel anti-impotence composition and a novel method for the treatment of impotence, whereby deacetyl moxisylyte or one of its non-toxic salts is administered in a ready to use aqueous solution by injection per intracavernosal route, as a drug inducing a substantially rigid penile erection.

Treatment of impotence

The present invention relates, by way of novel industrial products, to the .beta.-D-phenylthioxyloside compounds of the formula ##STR1## in which: X represents a sulfur atom or an oxygen atom;

.beta.-d-phenylthioxylosides, and their use as therapeutic agents

The present invention relates, by way of novel industrial products which are useful in therapy, to the benzopyranone-.beta.-D-thioxyloside compounds of the formula ##STR1## in which: one of the substituents R or R' is an oxygen atom double-bonded to the corresponding cyclic carbon atom and the other is a group R.sub.1,

Benzopyranone-.beta.-D-thioxylosides and their use in therapy

.beta.-D-phenylthioxylosides, their method of preparation and their use

The present invention relates, by way of novel industrial products, to osides selected from the group consisting of:

Novel beta-d-phenylthioxylosides, their method of preparation and their

The present invention relates to .beta.-D-phenylthioxyloside compounds selected from the group consisting of:

Novel .beta.-D-phenylthioxylosides, their method of preparation and

The present invention relates to novel asymmetrical esters derived from 1,4-dihydropyridine-3,5-dicarboxylic acid, of the formula: ##STR1## in which: R.sub.1 represents a C.sub.1 -C.sub.4 alkyl group, R.sub.2 represents a C.sub.1 -C.sub.4 alkyl group, a benzyl group, a benzoyl group or a phenyl group optionally substituted by one or more C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkyl, cyano, nitro, hydroxyl or trifluoromethyl groups or by one or more halogen atoms, and R.sub.3 and R.sub.4, which are identical or different, each represent the hydrogen atom, a nitro group or a chlorine atom, their optical isomers and diastereoisomers and also the corresponding addition salts. These novel esters are useful in therapy, especially as antihypertensives.

Asymmetrical ester derivatives of 1,4-dihydropyridine-3,5-dicarboxylic

The present invention relates to novel asymmetrical esters derived from 1,4-dihydrophyridine-3,5-dicarboxylic acid, of the formula: ##STR1## in which: R.sub.1 represents a C.sub.1 -C.sub.4 alkyl group, R.sub.2 represents a C.sub.1 -C.sub.4 alkyl group, a benzyl group, a benzoyl group or a phenyl group optionally substituted by one or more C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkyl, cyano, nitro, hydroxyl or trifluoromethyl groups or by one or more halogen atoms, and R.sub.3 and R.sub.4, which are identical or different, each represent the hydrogen atom, a nitro group or a chlorine atom, their optical isomers and diastereoisomers and also the corresponding addition salts. These novel esters are useful in therapy, especially as antihypertensives.

Asymmetrical ester derivatives of 1,4-dihydrophyridine-3,5-dicarboxylic

Intermediate products usable in particular for preparing corresponding amino derivatives by converting their nitro function, said products being of formula: ##STR1## in which: R.sub.1, R.sub.2 and R.sub.3, which are identical or different, each represent an atom of hydrogen, a halogen, a lower alkyl group or a lower alkoxy group;

Benzoyl-phenyl-piperidine derivatives

The present invention relates, by way of new industrial products, to the benzylphenyl osides of the formula ##STR1## in which: X.sub.1, X.sub.2, X.sub.3, X.sub.4 and X.sub.5, which are identical or different, each represent a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.4 alkyl group substituted by one or more halogen atoms (in particular a CF.sub.3 group), an OH group, a C.sub.1 -C.sub.4 alkoxy group, a C.sub.1 -C.sub.4 alkoxy group substituted by one or more halogen atoms, a nitro group, a group NR'R' (in which R' and R', which are identical or different, each represent the hydrogen atom, a C.sub.1 -C.sub.4 alkyl group or an acetyl group), a methylthio group, a methylsulfinyl group or a mesyl group, and

Benzylphenyl osides, method of preparation and use therefor

The present invention relates to new benzoyl-phenyl-piperidine derivatives selected from the group consisting of:

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Saulon Larue, France

Francois Bellamy