Rhone-Poulenc Rorer S.a.

Rhone-Poulenc Sante

Francois Audiau

Serge Mignani

Patrick Jimonet

Arielle Genevois-Borella

Jean-Claude Aloup

Dominique Damour

Claude Gueremy

Yves Ribeill

Claude James

Christian L Renault

Michel Barreau

Imidazo (1,2-A)-Indeno (1,2-E) pyrazin-4-one derivatives and

Imidazo�1,2-A! pyrazine-4-one, preparation thereof and drugs containing

Process for the preparation of 2-amino-4-nitrobenzothiazole derivatives

1,2,4-thiadiazino[3,4-b]benzothiazole derivatives, and medicinal

Pharmaceutical compositions are disclosed. They are useful for the treatment of medical conditions associated with the effects of glutamate, comprise as active principle, at least one compound of formula: ##STR1## or a salt thereof, in which either R.sub.1 represents polyfluoroalkoxy, 2,2,2-trifluoroethyl, pentafluoroethyl, tert-butyl, trimethylsilyl or trifluoromethylthio and R.sub.2 and R.sub.3 represent hydrogen,

Pharmaceutical compositions, 2-benzothiazolamine derivatives, and their

5-Trifluoromethoxy-2-benzimidazolamine and its salts with an inorganic or organic acid, its preparation and medicinal products containing it.

5-trifluormethoxy-2-benzimidazolamine compounds

Compounds of formula: ##STR1## and their salts, in which R.sub.1 represents polyfluoroalkoxy, and R.sub.2 represents alkyl, alkenyl (3-6 C), [cycloalkyl (3-6 C)]-alkyl, carbamoylalkyl, dialkylcarbamoylalkyl, acylaminoalkyl, phenylthioalkyl, hydroxyalkyl, cyanoalkyl, sulphamoylethyl, N-alkylsulphamoylethyl, pyridylthioalkyl, pyridiylalkylthioalkyl, pyridylsulphinylalkyl, alkynyl (3-6 C), phenylsulphinylalkyl, halophenylthioalkyl, (2,2,2-trifluoroethylthio)alkyl, 2-dialkylaminopropyl, pyrimidinylsulphinylalkyl, pyridylalkylsulphinylalkyl, halophenylsulphinylalkyl or (2,2,2-trifluoroethylsulphinyl)alkyl are useful in the treatment of medical conditions associated with the effects of glutamate.

2-imino-6-polyfluoroalkoxybenzothiazole derivatives, and pharmaceutical

2-imino-6-polyfluoroalkoxybenzothiazole derivatives, and pharamaceutical

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Charenton Le Pont, France

Francois Audiau