3m Innovative Properties Company

Solventum Intellectual Properties Company

Francois Ahimou

G Marco Bommarito

Naiyong Jing

William E Foltz

Tonya D Bonilla

Kelvin J Witcher

Kurt J Halverson

Robert A Asmus

Tushar A Kshirsagar

Sailaja Chandrapati

Louis C Haddad

Michael G Williams

Timothy J Nies

Joshua Erickson

Andrew W Vail

Heather M Webb

Ruthann R Duda

Assumpta A G Bennaars-Eiden

Hsi-Chou Liu

Kai Qiu

Swarnalatha Swaminathan

Assumpta Bennaars-Eiden

The present disclosure is directed to self-contained biological indicators wherein a single type of indicator is capable of being used for various sterilization conditions, including sterilization with steam and/or ethylene oxide. In some embodiments, a single type of biological indicator is capable of being used for different steam sterilization conditions having varied temperatures and sterilization cycles.

Self-contained biological indicator

A method is provided. The method includes providing an article, the article including a nonwoven substrate having a copolymer grafted thereto, the copolymer including interpolymerized monomer units of a quaternary ammonium-containing ligand monomers; an amide monomer; an oxy monomer; and a coating on the nonwoven substrate, the coating including a plurality of test microorganisms, an enzyme or a second substrate; and contacting the article with a detection medium for a period of time.

Methods to detect microorganisms

A device for monitoring the effectiveness of a decontamination process, the device including a bacteria cell as the indicator test organism and optionally a substrate, where the indicator test organism may include acell, and methods of using the monitoring device to evaluate the efficacy of a decontamination process.

Device for monitoring efficacy of a decontamination process comprising a bacteria cell and method of using

A biological sterilization indicator device is provided. The device comprises a body, a plurality of test microorganisms, and an oxygen-modulated first fluorescent sensor. The body comprises a first layer attached to a second layer, forming at least one isolatable microchamber and at least one primary passageway that provides fluidic communication between ambience and the at least one microchamber. The microchamber has an isolated volume of about 0.5 microliters to about 9.5 microliters. The plurality of test microorganisms and the oxygen-modulated first fluorescent sensor are disposed in the microchamber. A method of using the device to determine the effectiveness of a sterilization process is also provided.

Biological sterilization indicator devices and methods of use

A composition for monitoring the efficacy of a decontamination process is provided, the composition comprising a cellulose polymer and a predetermined quantity of an adenine nucleotide. A monitoring device comprising a test element with the composition disposed thereon is also provided. The composition and/or monitoring device can be used in a method. The method includes exposing the monitoring device to a decontamination process and subsequently measuring the residual tracer analyte on the monitoring device.

Wash monitor composition, device, and method of use

An article and method are provided for assessing the efficacy of a sterilization process. The article comprises an outer container having an interior volume; a dry source of measurable biological activity disposed in the interior volume; and an effective amount of a dry agent for neutralizing a sterilant compound; wherein both the source of measurable biological activity and the agent are in vapor communication with an environment outside the outer container. The method comprises exposing the article to a first sterilant and, optionally, a second sterilant for a period of time and detecting the measurable biological activity.

Biological indicator for monitoring a low-temperature sterilization process

Sterilization indicators that include a neutralizer, such indicators useful for testing the effectiveness of a sterilization procedure by measuring the activity of an active enzyme whose activity is correlated with the survival of microorganisms.

Self-contained sterilization indicators including a neutralizer for residual oxidizing sterilant

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Woodbury, MN, United States of America

Francois Ahimou