Snamprogetti S.p.a.

Eni-ente Nazionale Idrocarburi

Franco Morisi

Walter Marconi

Francesco Bartoli

Francesco Pittalis

Delio Zaccardelli

Roberto Gianna

Giulio Prosperi

Dino Dinelli

Silvio Gulinelli

Silvia Giovenco

Giuseppina Spotorno

This invention relates to chemical products of general formula ##STR1## wherein R is an amino group, mono or bi-hydroxyalkyl substituted, or a thio group, mono hydroxyalkyl substituted, in which one or more of the available --OH groups have been esterified with acids containing 2 to 18 carbon atoms. It is also described a process for the preparation of said products, which comprises reacting a corresponding starting compound, N or S-hydroxyalkyl substituted, with the chloride or the anhydride of the acid concerned.

Treating pain, inflammation and/or platelet aggregation

Fibres for biological uses can be produced by adding to a spinnable solution of a polymer selected from among many of the most common polymers and copolymers, a substance selected from among anti-platelet aggregation substances, anticoagulants and substances having a similar action. The substances can also be applied as a surface outer layer to articles made with the polymeric substances.

Bio-compatible porous fibres and materials for occluding biologically

Polyamide materials for the construction of protheses and surgical sundries are made biocompatible by inducing a superficial hydrolysis by treating such materials, either raw or in the form of shaped articles, with a normal multiple solution of hydrogen chloride. Thrice normal or fourfold normal solutions are preferred and the treatment time being a function of the temperature. At human body temperature (37.degree. C.) a treatment time from 30 to 60 minutes will do.

Superficially hydrolyzed biocompatible polyamide material

A method is disclosed for embedding sequestering agents in filamentary structures, the method comprising the steps of preparing an emulsion formed by an aqueous or nearly aqueous solution of the sequestering agent and a solution of the filament-forming polymer in an appropriate solvent, and spinning the emulsion in a coagulation bath.

Method for occluding sequestering agents in filamentary structure,

Phenylalanine level in blood or another medium is considerably reduced and can even be annulled by causing blood or the other medium to flow through a mass of porous fibers in which the enzyme phenylalanine ammonia lyase has been occluded: the fibers have been previously made biocompatible, if necessary.

Phenylalanine ammonia lyase occluded fibers for reducing phenylalanine

Biocompatible articles are obtained by treating a polymeric material with a hydrolyzing agent on its surface and covalently binding thereon a biological agent, such as an anti-platelet-aggregation agent.

Preparation of non-thrombogenic polymeric material article with platelet

For effecting enzymic reaction, a reactor is disclosed, in which the flow of the solution to be treated through the catalytic bed material takes place radially. It is preferred to have the catalytic bed in the form of coils of enzyme-occluding fibers. The coils are variously piled up within the reactor. High outputs, low pressure drops and more than satisfactory conversion rates are obtained.

Radial reactor for enzyme-catalyzed reactions

A method is disclosed for improving the activity of oxireductase enzymes, the improvement consisting in that an enzyme and a previously functionalized coenzyme are embedded in a filamentary structure, the coenzyme having previously been attached to a water-soluble, high-molecular-weight polymer.

Method for improving the activity of oxireductase enzymes embedded in

A process for the preparation of only one of the two stereoisomer forms carbamyl amino acids is provided wherein certain heterocyclic compounds having an assymmetrical carbon, such as 5-substituted hydantoins, are hydrolyzed in the presence of certain enzymes, such as dihydropyrimidinase extracted from calf liver. In another embodiment of the invention, the corresponding amino acids are provided by hydrolyzing the carbamyl amino acids in the presence of these same enzymes.

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San Giovanni in Persiceto, Italy

Franco Morisi