Zach System S.p.a.

Zambon S.p.a.

F.i.s. Fabbrica Italiana Sintetici S.p.a.

Franco Massaccesi

Livius Cotarca

Paolo Maragni

Johnny Foletto

Raffaella Volpicelli

Massimo Verzini

Ivan Michieletto

Ilaria Munari

Elisa Melotto

Franco Pellacini

Mauro Napoletano

Dario Braga

Gabriele Morazzoni

Roberto Brescello

Angelo Restelli

Vincenzo Frega

Alessandro Di Maria

Dario Università Di Bologna Braga

The present invention relates to a process for preparing a ketosulfone derivative and, more particularly, to an improved method for synthesizing 1-(6-methylpyridin-3-yl)-2-[(4-methylsulfonyl)-phenyl]ethanone by means of Pd-catalized alpha arylation process of a heteroaromatic ketone derivative.

Process for preparing a ketosulfone derivative

The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer l-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-1,3 dioxolane-4-carbaldehyde and a vinyl Grignard reagent.

Process for preparing nebivolol

The present invention relates to a process for reducing a compound of formula (I) wherein X is halogen, a hydroxy group, an alkylsulfoniloxy group or an arylsulfonyloxy group; to give a compound of formula (II) as a diastereoisomerically pure compound of RS/SR configuration characterized in that said reduction is carried out by the use of (+)-B-chlorodiisopinocampheylborane or (&#x2212;)-B-chlorodiisopinocampheylborane. The compounds of formula (II) are useful as intermediates for the preparation of Nebivolol. 

The present invention relates to macrolide compounds endowed with antiinflammatory activity and more particularly relates to new stable crystalline forms of a macrolide derivative with antiinflammatory activity, processes for the preparation of such forms, pharmaceutical compositions containing them as active ingredient and the use of said crystalline forms for the treatment of inflammatory diseases.

Crystalline forms of macrolide compounds endowed with antiinflammatory activity

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Grancona, Italy

Franco Massaccesi