Physion S.r.l.

Other

Franco Lugnani

Robert L Stephen

Silvio Eruzzi

Cino Rossi

Manfred Stohrer

Umberto Fontanella

Donald P Griffith

Augustinus Kramer

A method of treating acute urinary outflow system obstruction caused by disease of the prostate gland by localised electromotive drug administration. The treatment comprises insertion within the prostatic urethra and within the bladder cavity of a urethral catheter which incorporates a specific electrode and is adapted to perform the electromotive administration of a drug or drug mixture into diseased prostatic tissues thereby resolving the pathologies without resorting to surgery.

Electromotive drug administration for treatment of acute urinary outflow

An intravesical method of treating dysfunctional bladder syndromes by Electromotive Drug Administration (EMDA) of local anaesthetic drugs, anti muscarinic drugs and sympathomimetic agents. The administration of said drugs combined with hydraulic bladder dilatation causes relaxation of the detrusor muscle, reversing the hypertonicity associated with dysfunctional bladder syndromes.

Method of treating dysfunctional bladder syndromes by electromotive drug

Device for the combined electropharmacological treatment of the bladder and the prostatic urethra including a bougie comprising a flexible tubular body, openings for connection to the outside, an opening in its tip and elastic sealing elements arranged perimetrically around it, the bougie being internally provided with a stem-like electrode having two independent conductors, one shorter than the other, and suitable to perform a combined electropharmacological treatment of the bladder and of the prostatic urethra.

Device and method for the combined electropharmacological treatment of

Intravesical electromotive administration of specified dye substances for localisation and treatment of occult bladder cancers, is disclosed. Innocuous dye substances will provide differential staining of cancerous and normal urothelium; and anticancer dye substances will demonstrate differential staining and also initiate therapy of cancerous lesions. The addition of vasodilating agents will accentuate the differential staining and further promote therapy of the cancerous sites.

Method for localization and therapy of occult bladder cancer

A method of treating schistosomal infestations by both adult worms and eggs-miracidia, residing in the veins, venules and nearby tissues either of the bladder and ureters or of the colorectal regions of the intestines, including the locally administration by iontophoresis of at least an antischistosomal drug in the form of a solution.

Method of treating schistosomal infestations by iontophoresis

A method of intracorporeal iontophoretic treatment of an internal hollow body organ containing a physiological ion-rich fluid environment by delivery to said hollow body organ of drug ions by means of an iontophoretic device inserted into said hollow body organ and comprising an active electrode which has the same polarity as the drug ions to be delivered. The method comprises direct measurement of the pH of said physiological fluid environment, whereby indirectly measuring its ionic composition and selecting accordingly the material of said active electrode so that it either can interact with ions contained in said physiological environment or allow the interaction of said environmental ions with water hydrolysis products so as to reduce the ionic species competitive with said drug ions during the iontophoretic process.

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Trieste, Italy

Franco Lugnani