Farmitalia Carlo Erba S.p.a.

Farmitalia Carlo Erba S.r.l.

Carlo Erba S.p.a.

Farmitalia Carlo Erba

Farmitalia Certo Erba S.p.a.

Franco Faustini

Carmelo Gandolfi

Angelo Fumagalli

Roberto Ceserani

Carlo Passarotti

Alessandro Andreoni

Maria M Usardi

Enrico Di Salle

Vittoria Villa

Paolo Lombardi

Achille Panzeri

Renato Pellegata

Roberto d'Alessio

Roberto D'Alessio

Fabrizio Orzi

William Fava

Roberto Cesarani

Renato Pellegate

Walter Moretti

Mario M Usardi

The invention relates to 6-substituted 10.beta.-alkynylestrene derivatives wherein the 6 substituent is amino, azido, halogen or an alkylidene group and to corresponding 6,7-dihalo analogs. The invention provides also a process for the preparation of the above compounds and pharmaceutical compositions containing same. The compounds of the invention are useful aromatase inhibitors and can be used, e.g., in the treatment of hormone-dependent tumors and prostatic hyperplasia.

6-Alkylidene 10 .beta.-alkynylestrene derivatives and pharmaceutical

The invention relates to 6-substituted androsta-1,4-diene-3,17-dione derivatives wherein the 6 substituent is an azido, amino or substituted amino group. The invention provides also a process for preparing the said compounds and pharmaceutical compositions containing same. The compounds of the invention are useful aromatase inhibitors and can be used, e.g., in the treatment of hormone-dependent tumors.

Steroidic aromatase inhibitors

The invention discloses 4-substituted androstendione derivatives of the following formula (I) ##STR1## wherein R is amino or substituted amino or azido,

4-amino androstendione derivatives and process for their preparation

16-Fluoro-16,17-didehydro prostanoids, processes for their preparation, compositions containing them and methods of using them are disclosed. The compounds and compositions have pharmaceutical utility including, for example, luteolytic activity.

16-fluoro-16,17-didehydro prostanoids and process for their preparation

The present invention relates to new furyl derivatives of 16-substituted prostaglandins, to a process for their preparation and to pharmaceutical and veterinary compositions containing them. The new compounds of the invention are optically active or racemic prostaglandins of the following formula (I) ##STR1## wherein R is

Furyl derivatives of 16-substituted prostaglandins

Omega furyl prostenynoic acids have been prepared.

13,14-Didehydro-prostaglandins and process for their preparation

Esters of 13,14-didehydro prostaglandins have been prepared.

Ester and amide derivatives of 13,14-didehydro prostaglandins

2-oxa-bicyclic prostaglandins are provided, together with methods for their preparation and pharmaceutical and veterinary compositions containing same. The compounds have a wide range of pharmacological utilities, such as hypotensive agents, vasodilatory agents, and anti-aggregating agents.

Certain PGI.sub.1 compounds and their pharmaceutical composition and

9-deoxy-9A-methylene-isosteres of PGI.sub.2, including processes for their preparation and pharmaceutical and veterinary compositions containing same, are disclosed. The compounds are useful as therapeutic agents, for example as anti-aggregating agents, disaggregating agents, and as vasodilators.

9-Deoxy-9A-methylene isosteres of PGI.sub.2 and process for their

Bicyclic prostaglandins and pharmaceutical and veterinary compositions containing them having numerous pharmaceutical or veterinary utilities, including, for example, hypotensive, vasodilatory, anti-aggregating, luteolytic, and cytoprotective activities. Processes for preparing the compounds and compositions are also disclosed.

Bicyclic prostaglandins and process for their preparation

Bicyclic prostaglandins and pharamaceutical and veterinary compositions containing them having numerous pharmaceutical or veterinary utilities, including, for example, hypotensive, vasodilatory, anti-aggregating, luteolytic, and cytoprotective activities. Processes for preparing the compounds and compositions are also disclosed.

Pharmaceutically useful 5,6-saturated PGI compounds

Novel optically active 13,14-dehydro-11-deoxy-prostaglandins having a phenyl or substituted-phenyl group on the lower side chain are disclosed.

13,14-Dehydro-11-deoxy-prostaglandins and process for their preparation

The present invention relates to 15-epi-derivatives of prostacyclin and its analogs, to a process for their preparation and to pharmaceutical and veterinary compositions containing them.

Certain 15-epi-prostacyclins

Bicyclic prostaglandins and pharmaceutical and veterinary compositions containing them having numerous pharmaceutical or veterinary utilities including, for example, hypotensive, vasodilatory, anti-aggregating, luteolytic, and cytoprotective activities. Processes for preparing the compounds are also disclosed.

Bicyclic prostaglandins

Bicyclic prostaglandins and pharmaceutical and veterinary compositions containing them having numerous pharmaceutical or veterinary utilities including, for example, hypotensive, vasodilatory, anti-aggregating, luteolytic, and cytoprotective activities. Processes for preparing the compounds and compositions are also disclosed.

Growing community of inventors

Milan, Italy

Franco Faustini