Sclavo Spa

Eniricerche S.p.a.

Franco Cardinali

Giuseppe C Viscomi

Maria G Longobardi

Antonio S Verdini

Antonello Pessi

Fabio Bonelli

Romano Di Trapani

Diana Boraschi

Stefano Censini

Alessandra Ziggiotti

This invention firstly provides a method for purifying particular compounds of peptide or pseudo-peptide structure in which the number of protonable basic functions is greater than the number of acid functions and which have a molecular weight of less than 1000 daltons, by ion exchange displacement chromatography. In the method of the present invention the stationary phase used is a cationic exchange resin or a cross-linked polymer matrix activated with acid groups; the transporter solvent used is water if the compound to be purified already possesses at least one net positive charge, or aqueous dilute solutions of inorganic or strong organic acids which protonate the basic groups of the peptide or pseudo-peptide to be separated without modifying the structure of the peptide compound, such as acetic acid, trifluoroacetic acid, formic acid, hydrochloric acid or sulphuric acid; the displacer compound used is a triethylenetetraammonium salt.

Method for purifying low molecular weight compounds of peptide or

A new mono-silylating agent of general formula (I)

New silylating agent for the preparation of chromatographic supports

New partially retro-inverted tuftsin analogues of general formula I ##STR1## wherein R represents the side-chain of the amino acids threonine, methionine or leucine

Partially retro-inverted tuftsin analogues, method for the preparation

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Rome, Italy

Franco Cardinali