Farmitalia Carlo Erba S.r.l.

Pharmacia Corporation

Pharmacia & Upjohn

Naxospharma S.r.l.

Farmitalia Carlo Erba

Farmitalia Carlo Ebra S.r.l.

Franco Buzzetti

Antonio Longo

Dario Ballinari

Maria Gabriella Brasca

Paolo Lombardi

Enrico Di Salle

Angelo Crugnola

Maristella Colombo

Sergio Penco

Natale Barbugian

Silvia Fustinoni

Carlo Battistini

Fabrizio Orzi

Sergio Vioglio

Antonella Ermoli

Mariangela Mariani

Felicita Greco

Andrea Guido Arcamone

Gabriella Maria Brasca

13-substituted 5,6-dihydrodibenzo[a,g]quinolizinium salt compounds of the general formula (I): processes for the preparation of said compounds, pharmaceutical compositions containing said compounds and the use of said compounds for the manufacture of medicaments suitable for the treatment of cancerous diseases.

Benzoquinolizinium salt derivatives as anticancer agents

The present invention relates to a method for preparing 2-alkoxy and 2-aryloxyestrogen compounds, and the intermediate compounds prepared during the use of this method, which intermediate compounds are useful intermediates in the preparation of certain physiologically active compounds.

Method and intermediates for preparing 2-alkoxy and 2-aryloxy estrogen compounds

Substituted tetralymethylen-Oxindoles analogues as tyrosine kinase

Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase

Aryl and heteroaryl purine compounds

Substituted quinolymethylen-oxindole analogues as tyrosine kinase

Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase

Substituted 3-arylidene-7-azaoxindole compounds and process for their

Substituted azaindolylidene compounds and process for their preparation

Arylidene and heteroarylidene oxindole derivatives of formula (I) ##STR1## wherein, subject to provisos, Y is a bicyclic ring system chosen from naphthalene, tetralin, quinoline and isoquinoline;

Arylidene and heteroarylidene oxindole derivatives and process for their

N-substituted .beta.-aryl- and .beta.-heteroaryl-.alpha.-cyanoacrylamide

The invention relates to compounds of formula ##STR1## wherein Ar is mono- or bicyclic ring system chosen from benzene, naphthalene, tetrahydronaphthalene, quinoline and indole;

Arylidene-heterocyclic derivatives and process for their preparation

The present invention provides compounds of the formula ##STR1## wherein Y is a naphthyl, tetrahydronaphthyl, pyridyl, quinolyl, isoquinolyl or indolyl ring system, R is a moiety which is an acrylic acid, a CN-substituted acrylic acid, acrylamide, acrylonitrile or thioacrylamide, or a group of formulae (e) to (j): ##STR2## wherein R.sub.3 is OH or NH.sub.2, R.sub.1 is H, alkyl or alkanoyl, R.sub.2 is H, halogen, CN or alkyl; and n is 0, 1, 2 or 3; and the pharmaceutically acceptable salts thereof are useful as tyrosine kinase inhibitors.

Arylethenylene compounds which are useful as tyrosine kinase inhibitors

The new use of a compound of formula (I) ##STR1## wherein Y is a bicyclic ring selected from naphthalene, tetralin, quinoline, isoquinoline and indole;

Biologically active 3-substituted oxindole derivatives useful as

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Monza, Italy

Franco Buzzetti