Merz Pharma Gmbh & Co Kgaa

Corneal Laboratoires

Franck Villain

Uwe Wortmann

Gilles Bos

Andreas Krause

Alexander Linko

Roland Stragies

Nadine Hagedorn

Angel Ortuno

Lubin Belkovi

Norbert Kaspers

Johannes Egger

Michael Kunz

Wolfgang Liebetrau

Radia El-Banna

Colin Drabe

Guido Popp

Jonathan Mason

Frank Pleis

The present invention generally relates to a mixing nozzle () for mixing at least two liquid compositions such as a first liquid composition and a second liquid composition. The mixing nozzle () is configured to be coupled to a body () of a multi-component application device (), in particular to a body () of a two-component syringe assembly, for injection of a liquid composition, which body () is configured to separately store said at least two solutions. The present invention further relates to a multi-component application device () comprising said mixing nozzle () and to a kit comprising said mixing nozzle () or said application device (). Furthermore, the present invention relates to a method using said application device or said kit, for example for replacing or filling a biological tissue or increasing the volume of a biological tissue.

Mixing nozzle, application device, kit and method using the mixing nozzle or application device

The present invention relates to the field of hyaluronic acid-based gel compositions suitable for use as soft tissue fillers, and more specifically to a novel method for crosslinking such compositions. The present invention further relates to compositions prepared by the novel crosslinking method and their use in cosmetic and therapeutic applications.

Method for producing crosslinked hyaluronic acid

The present invention generally relates to a modified hyaluronic acid (HA) and to a method for making same, more specifically to a (poly)glycerol-modified HA derivative prepared by grafting glycidol to HA. The present invention also relates to the use of the HA derivative for preparing a dermal filler composition, a hydrogel comprising cross-linked HA and the (poly)glycerol-modified HA derivative, and a method for preparing said hydrogel. Furthermore, the present invention relates to the use of the hydrogel as a cosmetic and/or aesthetic product, in particular as a dermal filler for tissue filling, replacing and/or augmenting.

Modified hyaluronic acid, method for making same and uses thereof

The present invention relates to a composition for the in vivo degradation of polysaccharide-containing fillers by radical degradation. The composition of the invention comprising at least one source of oxygen free radicals and at least one catalyst of oxygen free radical generation from the at least one source of oxygen free radicals. The present invention further relates to methods and uses of said composition for filler correction or reversal.

In vivo accelerated degradation of polysaccharide-containing fillers

The present invention relates to injectable dermal filler compositions in the form of a gel, comprising hyaluronic acid (HA), carboxymethyl cellulose (CMC) and, optionally, microparticles such as calcium hydroxyapatite (CaHAP) microparticles. The injectable dermal filler compositions have improved rheological properties while at the same time have low extrusion forces. The present invention further relates to a method for preparing such injectable dermal filler compositions and their use for cosmetic and therapeutic purposes.

Dermal filler based on crosslinked hyaluronic acid and carboxymethyl cellulose lubricant

The present invention relates to polysaccharide soft tissue fillers comprising heparosan and processes for their preparation. The polysaccharide soft tissue fillers of the present invention are advantageously used in therapeutic or cosmetic applications such as for the filling of wrinkles.

Polysaccharide soft tissue fillers with improved persistence

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Paris, France

Franck Villain