Advanced Accelerator Applications Sa

Dompe S.p.a.

Istituto Nazionale Per Lo Studio E La Cura Dei Tumori

Geymonat S.p.a.

Fondazione Irccs Istituto Nazionale Dei Tumori

Franck Martin

Mariangela Figini

Gian Maria Rossolini

Silvana Canevari

Giuseppe Salvia

Vito Di Cioccio

Gaetano D'Anniballe

Margherita Cattozzo

Giovanni Maurizi

Stefano Cencioni

Antonella Colagrande

Maria Cristina Thaller

Marco Maria D'Andrea

The present invention relates to a new homodimeric form of recombinant PlGF-1, to a process for its preparation and to compositions containing it.

PlGF-1 in homodimeric form

Antibody or fragment thereof, which specifically binds to folate receptor-alpha (FR&#x3b1;), wherein said antibody or fragment thereof comprises a light chain whose variable region comprises at least one of the following amino acid sequences: &#x2014;RASESVSFLGINLIH (SEQ ID NO: 3), &#x2014;QASNKDT (SEQ ID NO: 4), &#x2014;LQSKNFPPYT (SEQ ID NO: 5), and wherein the constant region of said light chain is a kappa constant region.

Human anti-folate receptor alpha antibodies and antibody fragments for the radioimmunotherapy of ovarian carcinoma

The present invention relates to a method of producing a recombinant protein comprising using a selection method other than antibiotics. In particular, it relates to a stable host/vector system based on the pyrC gene complementation designed to produce high level of heterologous recombinant protein in The expression system of the present invention allows rapid selection of plasmid containing cells during the cloning phases and lead to high protein expression during fermentation. This system has a strong selective efficiency, especially during the induction phase, leading to the selection of an almost homogeneous and stable plasmid bearing cell population. Moreover the productivity of the culture is to a large extent better than the one based on antibiotic resistance.This elevated vector stability combined with its high productivity fulfils the requirements for heterologous protein production into an industrial level.

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L'Aquila, Italy

Franck Martin