Centre National De La Recherche Scientifique

Commissariat a L'energie Atomique

Université De Bourgogne

Other

L'air Liquide, Societe Anonyme a Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude

L&prime;air Liquide-societe Anonyme a Directoire Et Conseil De Surveillance Pour L&prime;etude Et L&prime;exploitation Des Procedes Georges Claude

Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Université De Cergy Pontoise

Université De Bourgogne Dijon

Franck Denat

Roger Guilard

Frederic Boschetti

Claire Bernhard

Henry Ledon

Pierre Montmeat

Michael Chorev

Gilles Lagrange

Ahmad Mehdi

Bruno Roux-Fouillet

Jean-Louis Babouhot

Michel Meyer

Yoann Rousselin

Pauline Desogere

Robert J Corriu

Catherine Reye

Eric Pasquinet

Hervé Chollet

Lionel Hairault

Stéphane Brandes

Claude Chuit

Jean-Michel Barbe

Arnaud Bucaille

Frédéric Boschetti

Victor Goncalves

Fr&eacute;d&eacute;ric Barbette

St&eacute;phane Brandes

Coline Canovas

G&eacute;rard Dubois

Rapha&euml;l Tripier

G&eacute;raud Dubois

Fanny Chaux

Claude Gros

Francois Cuenot

Frédéric Rascalou

Anna Maria Rovero

François Cuenot

Debora M D'Addona

A modular tetrazine platform, can be used as diagnostic, theragnostic agent and/or medicinal product. An inverse electron demand Diels-Alder reaction can be used for synthesizing bifunctionalized tetrazines, which can be obtained from monofunctionalised tetrazines.

Biocompatible modular tetrazine platform

A compound with formula (V') the synthesis method for compound (V&#x2032;), and its use for the preparation of 1,4,7-triazacyclononane (tacn) and N- and/or C-functionalized derivatives thereof, particularly compounds with formula (I) Also, metallic complexes comprising a ligand with formula (I) and a metal and their use for imaging.

Synthesis of imidazo[1,2-a]pyrazin-4-ium salts for the synthesis of 1,4,7-triazacyclononane (tacn) and N- and/or C- functionalized derivatives thereof

The present invention embodiments relate to a compound with formula (V')  The invention also relates in certain embodiments to the synthesis method for compound (V&#x2032;) and its use for the preparation of 1,4,7-triazacyclononane (tacn) and N- and/or C-functionalized derivatives thereof, particularly compounds with formula (I)  The invention also relates in certain embodiments to metallic complexes comprising a ligand with formula (I) and a metal and their use for imaging.

Synthesis of imidazo[1,2-a]pyrazin-4-ium salts for the synthesis of 1,4,7-triazacyclononane (tacn) and N- and/or C-functionalized derivatives thereof

The present invention relates to a material notably adapted for the extraction of metal cations in an aqueous medium, comprising a solid support on which are attached polyazacycloalkane compounds having a ring including at least 4 nitrogen atoms, and wherein the nitrogen atoms of the ring are substituted with coordinating groups, which each are independently: The invention also relates to methods for preparing the aforementioned materials and to different uses thereof, notably for the extraction of Pbcations in an aqueous medium.

Materials for the solid/liquid extraction of heavy metal ions, containing supported N-functionalized polyazacycloalkanes

Material composed of a polyazacycloalkane grafted on polypropylene fibres. Process for the preparation of this material. Process for removing metal cations present in a liquid by bringing this liquid into contact with the said material.

Material comprising polyazacycloalkanes, grafted on polypropylene fibres, its process of preparation, and process for removing metal cations from a liquid

The invention relates to the use of molecular tweezers as sensitive materials in chemical sensors intended to detect or assay organic compounds in the vapour state, and in particular nitro compounds. These molecular tweezers correspond to the general formula (I): in which: Fields of application: detection of explosives, control and monitoring of atmospheric pollution and of the quality of ambient air in relatively confined spaces, and monitoring of industrial sites.

Use of molecular tweezers as sensitive materials in chemical sensors for detecting or assaying organic compounds in the vapour state

A method of preparing cyclene having formula (I) from triethylenetetraamine having formula (VIII) or ethylenediamine having formula (VIII') includes a series of steps. The first series of steps (I) includes a step A (one-pot preparation of the compound having formula (IIa) from the compound having formula (VIII)), followed by a step B (transforming the compound having formula (IIa) into cyclene having formula (I)). The second series of steps (II) includes a step C (preparing the compound having formula (IIb) from the compound having formula (VIII)), followed by a step D (transforming the compound having formula (IIb) into cylcene having formula (I)). The third series of steps (III) includes a step E involving the onepot preparation of the compound having formula (IIa) from the compound having formula (VIII), followed by a step B involving the transformation of the compound having formula (IIa) into cyclene having formula (I).

Method of preparing cis-8b-methyldecahydro-2a,4a,6a,8a-tetraazacyclopenta[fg]acenaphthylene, cis-decahydro-2a,4a,6a,8a-tetraazacyclopenta[fg]acenaphthylene, cyclene and functionalised cyclenes

The invention relates to a method of preparing nitrogen macrocycles having formula (I). The inventive method comprises a step involving the reaction of compounds (II) and (III) in order to form a compound having formula (IV). Said compound is subsequently made to react with a compound having formula (V) in order to form a compound having formula (VI). The latter compound is then subjected to an acid treatment 

Method of preparing nitrogen macrocycles

Silica gel incorporating polyazacycloalkane units comprising more than six nitrogen atoms, preparation process and use

A novel compound which can be used in the field of separation and purification of gases is disclosed. The compound can be incorporated into a silica gel incorporating polyazacycloalkane structural units for separating a predetermined gas from a mixture of gases. The mixture of gases is brought into contact with a metallated hybrid gel under conditions which make possible the absorption of the gas to be separated, followed by a phase of desorption of the attached gas, and the recovery of the gas.

Silica gel incorporating polyazacycloalkane structural units

The invention concerns a method for preparing polyazacycloalkanes immobilised on a silica gel from a polyazacycloalkane of formula (A) in which: R and R represent a hydrogen atom, an alkyl radical, or a &lsqb;hetero(aryl)&rsqb;alkyl radical; W , W and W represent a radical of formula (B): &mdash;&lsqb;(CT T ) &mdash;&lsqb;N(R )&rsqb; &mdash;(CT T ) &rsqb; &mdash; such as defined in the description; R represents a hydrogen atom, an alkyl radical or a &lsqb;hetero(aryl)&rsqb;alkyl radical, provided that the polyazacycloalkane ring of the compound of formula (A) comprises not more than 30 cyclic carbon atoms, and not more than 6 cyclic nitrogen atoms. The invention is characterised in that: (a) the compound of formula (A) is reacted with a compound of formula (C): Z&mdash;R &mdash;Si(X )(X )(X ), such as defined in the description to form a compound of formula (D); (b) said compound of formula (D) is condensed on the silanol sites of a silica gel to form the immobilised polyazacycloalkane of formula (E); and (c) some ethanol sites having not reacted are, if required, protected by Z&prime;, a group protecting the hydroxyl function. The invention is useful for separating oxygen from air.

Method for preparing polyazacycloalkanes grafted on silica gel and use of grafted compounds

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Dijon, France

Franck Denat