Commissariat a L'energie Atomique

Ipsen Pharma S.a.s.

Centre National De La Recherche Scientifique

Le Centre National De Recherche Scientifique (cnrs)

Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Franck Artzner

Roland Cherif-Cheikh

Jean-Christophe Cintrat

Bernard Rousseau

Marie-Thérèse Paternostre

Céline Valery

Stéphane Roux

Melinda Ligeti

Maarten Ijsselstijn

Christophe Tarabout

Nicolas Fay

Roland Cherif-cheikh

The present invention relates to novel octapeptide compounds of general formula (I): H-2-Nal-cyclo(Cys-Tyr-AA-Lys-Val-Cys)-Thr-NH. Since these products have a good affinity for certain somatostatin receptor subtypes, they are particularly advantageous for treating pathological states or diseases in which one (or more) somatostatin receptor(s) is (are) involved. These compounds furthermore have physiochemical properties that make it possible to envisage them in diverse solutions for the formulation of medicaments, for example as a pharmaceutically acceptable carrier. The invention also relates to pharmaceutical compositions containing said products and to the use thereof for the preparation of a medicament.

Octapeptide compounds derived from somatostatin and the therapeutic use thereof

The present invention relates to novel octapeptide compounds of general formula (I),R-AA-cyclo(AA-Tyr-D-Trp-AA-Val-Cys)-Thr-NH&#x2003;&#x2003;(I)As these products have a good affinity for certain sub-types of somatostatin receptors, they are particularly useful for treating the pathological states or diseases in which one (or more) of the somatostatin receptors is (are) involved. The invention also relates to pharmaceutical compositions containing said products and their use for the preparation of a medicament.

Octapeptide compounds and therapeutic use thereof

Growing community of inventors

Cesson Sevigne, France

Franck Artzner