Technische Universiteit Eindhoven

Xeltis Ag

Stentit B.v.

Stichting Voor De Technische Wetenschappen

Universitaet Zuerich

Xeltis B.v.

Unversität Zürich

Franciscus Petrus Thomas Baaijens

Patricia Yvonne Wilhelmina Dankers

Martijn Antonius Johannes Cox

Anton Willem Bosman

Tristan Mes

Tom Lavrijsen

Anandkumar Nandakumar

Carolina Victoria Catharina Bouten

Bart Sanders

Maria Sol Cabrera

Henricus Marie Janssen

Simon Philipp Hoerstrup

Serge Hendrikus Mathijs Söntjens

Anita Driessen-Mol

Sandra Vossen-Loerakker

Mirjam Petronella Rubbens

Jeroen Kortsmit

Niels Jozef Bart Driessen

Marcel Cornelis Maria Rutten

Serge Hendrikus Mathijs SÖNTJENS

A stent composed by a bioabsorbable network of polymer fibers that can be rearranged upon expansion, accommodating for diameter enlargement without the need of a strut or strut pattern and providing temporary support to a biological duct, is provided. Additionally, a stent is provided where the rearranged fibrous network of its expanded state can act as a scaffold for cell infiltration and promote autologous tissue formation.

Fibrous tubular conduit for stenting applications

The disclosure lies in the field of regenerative medicine and relates to an implant having a matrix material, and a method for manufacturing an implant having matrix material. The disclosure further relates to a crimped implant.

Implant

Various inserts, called shapers and spacers, are provided for controlling tissue engineered heart valve (TEHV) leaflet geometry during culture. These inserts will prevent TEHV leaflet retraction during culture, be able to control the leaflet geometry during culture, enable culturing TEHV leaflets with a larger coaptation area, control the height of the coaptation area, maintain TEHV leaflet curvatures, and/or enable possibilities to culture TEHV leaflets in open configuration.

Controlling tissue engineered heart valve geometry by using predefined inserts during culture

The invention relates to a method for producing a preform by means of an electrospinning process. The present invention also relates to the use of the present preform as a substrate for growing human or animal tissue thereon. The present invention furthermore relates to a method for growing human or animal tissue on a substrate, wherein the present preform is used as the substrate.

Preform produced by electrospinning, method for producing the same and use of such a preform

The invention relates a multilayer preform obtained by electro-spinning, which preform is suitable as a scaffold for a prosthesis, which preform comprises at least one layer of microfibers and at least one layer of nanofibers, wherein the pore size of the at least one layer of microfibers is in the range of 1-300 micrometer and in that the pore size of the at least one layer of nanofibers is in the range of 1-300 micrometer. The present invention also relates to a method of producing said preform. The present invention also relates to the use of the present preform as a substrate for growing human or animal tissue thereon. The present invention furthermore relates to a method for growing human or animal tissue on a substrate, wherein the present preform is used as the substrate.

Multilayer preform obtained by electro-spinning, method for producing a preform as well as use thereof

Method for manufacturing a tissue-engineered construct, such as a heart valve, comprising the steps of providing a-cell-seeded scaffold in a bioreactor chamber which bioreactor chamber is divided by the cell-seeded scaffold into a first compartment and a second compartment, subjecting the cell-seeded scaffold to a flow of nutrient medium within the bioreactor chamber for developing the cell-seeded scaffold to a tissue structure and next to the tissue construct, applying a dynamic pressure difference to the developing tissue structure by the flow of nutrient medium to induce dynamic strain on the tissue structure.

Method for manufacturing a tissue-engineered construct

Growing community of inventors

Eindhoven, Netherlands

Franciscus Petrus Thomas Baaijens