Dsm IP Assets B.v.

Tibotec Pharmaceuticals Ltd.

Franciscus Alphons Lommen

Daniel Mink

Dennis Heemskerk

Sven Panke

Robert Jan Vijn

Joannes Gerardus Kierkels

Constantinus Simon Liebregts

Jacob Hermanus Kooistra

Bart Rudolf Kesteleyn

Peter Jan Quaedflieg

The invention relates to a process for the preparation of a 2,4-dideoxyhexose or a 2,4,6-trideoxyhexose from a substituted or unsubstituted carbonyl compound with at least 2 carbon atoms and at least one &#x3b1;-hydrogen atom and a substituted or unsubstituted aldehyde in the presence of an aldolase and water, the reaction between the substituted or unsubstituted carbonyl compound with at least 2 carbon atoms and at least one &#x3b1;-hydrogen atom and the substituted or unsubstituted aldehyde being carried out at a carbonyl concentration of at most 6 moles/l of reaction mixture and the final concentration of the 2,4-dideoxyhexose or the 2,4,6-trideoxyhexose being at least 2 mass % of the reaction mixture. The invention also relates to the use of a 2,4-dideoxyhexose or a 2,4,6-trideoxyhexose obtained by means of a process according to the invention in the preparation of a medicine, particularly in the preparation of a statine.

Process for the preparation of 2,4-dideoxyhexoses and 2,4,6-trideoxyhexoses

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SM Horst, Netherlands

Franciscus Alphons Lommen