Pharma Mar, S.a.

Marrone Bio Innovations, Inc.

Francisco Romero Millan

Dolores Garcia Gravalos

Julia Perez Baz

Teresa Garcia De Quesada

Glynn Thomas Faircloth

Cristina Acebal Sarabia

Daniel C Leep

Lisa Doricchi

Maria Julia Perez Baz

Rosa Isabel Fernandez Chimeno

Librada M Fernandez

Daniel Leep

The use of a bacterial secondary metabolite, thaxtomin is described as an effective herbicide on broadleaved, sedge and grass weeds, e.g., in rice fields with no phytotoxicity to rice as well as on aquatic based weeds.

Use of thaxtomin for selective control of rice and aquatic based weeds

The present invention is directed to a novel depsipeptide has been isolated from a new marine strain L-13-ACM2-092 belonging to the family Micromonosporaceae. Its production by aerobic fermentation under controlled conditions of the strain, and the isolation and purification of PM-93135 are described herein. The compound and the fermentation broth demonstrate significant activity against several cancer cell lines. The compound also shows activity against several gram positive bacteria.

Method of treating tumors with thiodepsipeptide isolated from a marine actinomycete

Thiodepsipeptide isolated from a marine actinomycete

The active component of the pharmaceutical composition of the present invention is a compound which has been isolated from the controlled aerobic fermentation of a marine microorganism, Agrobacterium sp. PH-103. The pharmaceutical compositions of the present invention, useful for post surgical graft tolerance, are thus directed to compositions comprising a pharmaceutically acceptable carrier, diluent or excipient, and an effective amount of the compound having the formula: ##STR1## This compound, known as Sesbanimide, is an alkaloid that has been previously been isolated from seeds and reported to be useful as an antitumor drug. Prior to the present invention however, this compound had not been isolated from any fermentation broth nor had it been determined to have immunomodulatory activity.

Immunosuppressive pharmaceutical compositions new biological activity

Growing community of inventors

Leon, Spain

Francisco Romero Millan