Lacer, S.a.

Lacer

Francisco Pubill Coy

Jose Repolles Moliner

Lydia Cabeza Llorente

Eduardo Salas Perez-Rasilla

Marisabel Mourelle Mancini

Juan Carlos Del Castillo Nieto

Cristina Negrie Rofes

Marcelli Carbo Banus

José Repollés Moliner

Alicia Ferrer Siso

Jos&eacute; Repolles Moliner

Ana Modolell Saladrigas

Jes&uacute;s Murat Moreno

Juan Martinez Bonnin

Juan Martínez Bonín

Juan-Antonio Cerda Riudavets

Nuria Trias Adroher

Anna Modolell Saladrigas

Pedro Michelena Llagundo

Carlos Malet Falco

Juan Antonio Cerda Riudavets

Joan Martínez Bonnin

Marek W Radomski

In the present invention there are disclosed new derivatives of dianhydrohexite mononitrate corresponding to formula (I), tautomers, pharmaceutically acceptable salts, prodrugs and solvates thereof: as well as pharmaceutical compositions comprising these compounds and uses thereof.

Disulfide, sulfide, sulfoxide, and sulfone derivatives of cyclic sugars and uses thereof

The present invention relates to new 3-substituted 6-nitrooxy-hexahydrofuro[3,2-b]furane derivatives possessing a superior pharmacological activity in thrombosis and in coronary ischemia models.

Isosorbide nitrates

This invention relates to a new method for the stereospecific thiocarboxylation and nitration of organic compounds for the preparation of compounds according to formula (I):      

Stereospecific method for the preparation of dioxa-bicyclooctane nitrate compounds

The present invention relates to stable S-nitrosothiols derivatives of formula (I) having vasodilating effect and which inhibit the aggregation of the platelets and which therefore are useful for the preparation of medicaments for treatment of NO related diseases. The invention also relates to a process for the synthesis of the compounds of formula (I).

Stable S-nitrosothiols, method of synthesis and use

This invention relates to a new method for the stereospecific thiocarboxylation of organic compounds for the preparation of compounds according to formula (I): wherein a compound of formula (II): is reacted with a compound of formula (IIIa) or (IIIb): then treating the obtained product with a thiocarboxylic acid or a salt thereof, and subsequently carrying out a nitration reaction.

Stereospecific method for the preparation of dioxa-bicyclooctane compounds

In the present invention there are disclosed new derivatives of dianhydrohexite mononitrate corresponding to formula (I), tautomers, pharmaceutically acceptable salts, prodrugs and solvates thereof as well as pharmaceutical compositions comprising these compounds and uses thereof. 

Disulfide, sulfide, sulfoxide, and sulfone derivatives of cyclic sugars and uses

Novel derivatives of isosorbide mononitrate and its pharmaceutically acceptable salts, which have vasodilating activity with a reduced effect of tolerance, of the general formula (I)in which A and B independently represent any of the groups&#x2014;ONOand &#x2014;Z&#x2014;CO&#x2014;R, wherein Z is an oxygen atom or sulphur atom and R is an alkyl C-Cgroup, an aryl group or an aralkyl group, eventually substituted, or the groupin which Ris hydrogen, or an alkyl C-Cgroup, an aryl group or an aralkyl group, eventually substituted, with the proviso that one of A or B is always &#x2014;ONO, but never both of them at the same time, when Z is an sulphur atom R is an alkyl C-Cgroup, an aryl group or an aralkyl group, eventually substituted, and when Z is an oxygen atom R is the group

Derivatives of isosorbide mononitrate and its use as vasodilating agents with reduced tolerance

S-nitrosothiols as agents for the treatment of circulatory dysfunctions

N-(.alpha.-substituted-pyridinyl)carbonyl dipeptide antihypertensive

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Barcelona, Spain

Francisco Pubill Coy