Instituto De Salud Carlos III

Fundacion Publica Andaluza Progreso Y Salud

Francisco Martin Molina

Marien Cobo Pulido

Pilar Munoz Fernandez

Karim Benabdellah El Khlanji

Miguel Garcia Toscano

The invention relates to expression systems useful for regulated expression of a gene of interest based on the constitutive expression of the original TetR repressor and the expression of the polynucleotide driven by a constitutive promoter operably linked to an operator sequence for a tetracycline operator sequence. The system can be provided as two different polynucleotides or as an all-in-one vector. The invention also relates to vectors, host cells and viral particles according to the invention as well as to the uses thereof for in vitro and in vivo production of products of interest or for therapy.

Growing community of inventors

Seville, Spain

Francisco Martin Molina