Bioiberica, S.a.

Francisco Javier Vila Pahi

Ramon Ruhi Roura

Carlos Raul Alaez Verson

Josep Escaich Ferrer

Ana Maria Torrent Gibert

Josep Verges Milano

August Lodewijk Verbruggen

Ricard Mis Vizcaino

Vicente Montiel Leguey

Vicente Garcia Garcia

Eduardo Exposito Rodriguez

Antonio Aldaz Riera

Narc&iacute;s Arnau Pastor

Francesc Flores Salgado

The present invention relates to the use of a sulphated polysaccharide in acid form or as a physiologically acceptable salt thereof, selected from the group constituting of inulin sulphate, gellan sulphate, pullulan sulphate, curdlan sulphate, alginiq acid sulphate, laminarin sulphate, and pectin sulphate, for the preparation of a medicament for the treatment or prophylaxis of arthrosis in a mammal. Preferably, the sulphated polysaccharide is inulin sulphate, most preferably inulin polysulphate sodium salt. The present invention also relates to the use of a sulphated oligosaccharide derived from a polysaccharide selected from the group consisting of inulin, gellan, pullulan, curdlan, alginic acid, laminarin, and pectin, for the preparation of a medicament for the treatment or prophylaxis of arthrosis in a mammal.

Therapeutic use for a group of sulphated polysaccharides

This invention relates to a process for the preparation of glucosamine sulfate, glucosamine hydroiodide, glucosamine pyruvate, glucosamine phosphate or their mixtures with glucosamine hydrochloride, by electrodialysis. Starting from glucosamine hydrochloride, the exchange of the Clfor an anion selected from the group consisting of SO, I, CHCOCOOand POtakes place during the process. The electrodialyser comprises a cathode, anode, and means of separation composed of anion exchange membranes, cation exchange membranes, bipolar membranes or by other suitable means of separation. This invention also relates to a glycosamine sulphate containing chlorides obtainable by the process, and its therapeutic use.

Process for the preparation of glucosamine salts

The invention relates to novel disaccharides of formula (I), wherein R is selected from the group consisting of hydrogen, linear or branched (C -C ) alkyl, phenylalkyl with less than ten carbon atoms and &mdash;COCH ; R is selected from the group consisting of hydrogen, &mdash;COCH and SO M; R is selected from the group consisting of hydrogen, linear or branched (C -C ) alkyl, phenylalkyl with less than ten carbon atoms, &mdash;COCH and y &mdash;COPh, Ph being phenyl; G is selected from amongst &mdash;COOR and &mdash;COOM, R is selected from the group consisting of hydrogen, (C -C )-alkyl and arylalkyl with less than sixteen carbon atom; A is selected from the group consisting of hydrogen, &mdash;SO H, &mdash;SO M and &mdash;COCH ; B is selected from the group consisting of hydrogen, &mdash;SO H, &mdash;SO M and &mdash;COCH , wherein either A or B are necessarily either &mdash;SO H or &mdash;SO M, M being a an organic or metallic cation. Said compounds can be used as anti-arthritic agents, anti-inflammatory agents or to control blood coagulation.

Disaccharides with anti-arthrosic properties

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Barcelona, Spain

Francisco Javier Vila Pahi