Consejo Superior De Investigaciones Cientificas

UniversitÄt Autonoma De Barcelona

Universidad De Barcelona

Francisco Javier Luque Garriga

José Luis Marco Contelles

Mercedes Unzeta López

Abdelouahid Samadi

Irene Bolea Tomás

The present invention relates to a compound of formula (I):  wherein: Rand Rare selected from among H and C1-C10 alkyl; Ris selected from among H, &#x2014;OR, N, &#x2014;CN, &#x2014;C(O)R, &#x2014;C(O)OR, &#x2014;C(O)NRR, &#x2014;C&#x2550;NR, &#x2014;OC(O)R, &#x2014;NRR, &#x2014;NRC(O)R, &#x2014;NO, &#x2014;N&#x2550;CRR, halogen and C1-C10 alkyl, wherein Rand Rare selected from among H, alkyl, alkenyl, cycloalkyl and aryl; X, Y, Z, Zand Zare selected independently from among CH and N; A is selected from among (CH), NH, O and CO, wherein n is an integer between 1 and 6, to the procedure for the obtainment of said compounds, to a pharmaceutical composition comprising said compound, and to the use thereof in the treatment of a neurodegenerative disease, more particularly treatment of Alzheimer's or Parkinson's disease.

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Barcelona, Spain

Francisco Javier Luque Garriga