Rubicon Scientific LLC

Bayer Aktiengesellschaft

Bayer Healthcare LLC

Francisco Cabrera

David R Jones

Gordon R Huber

Kevin D Kuenzi

John C Kuenzi

Martin Scheer

Hubert Rast

Ernst Heinen

Reinhold Lohr

Matthias Kuhn

Oliver Vetter

The present invention relates to a solid dispersion of quinolone- or naphthyridonecarboxylic acids in an insoluble matrix representative of a shellac, and methods preparing and using the same in masking the taste and improving the uptake by animals.

Solid phase dispersion of quinolone or naphthyridonecarboxylic acids

Improved extrusion-processed daily ration animal feeds are provided which include minor amounts of actives to ensure that an animal consuming the feed receives quantities of the actives sufficient to establish and maintain substantially constant concentrations of the actives in the animal's bloodstream. The feeds may be produced by extrusion with addition of minor quantities of one or more actives so as to uniformly distribute the actives throughout the extruded product.

Animal feeds including actives and methods of preparing same

Improved daily ration mammal feeds are provided which include minor amounts of heartworm preventative drugs, ensure that a mammal consuming the feed receives quantities of drug sufficient to establish and maintain substantially constant concentrations of the drug in the pet's bloodstream. The feeds may be produced by extrusion with addition of minor quantities of heartworm preventative drug so as to uniformly distribute the drug throughout the extruded product. Ivermectin levels of from about 2-1500 &#x3bc;g/kg of extruded feed are preferred.

Animal feeds including heartworm-prevention drugs

Improved ivermectin-containing daily ration extruded feeds for domesticated household pets such as cats and dogs are provided so that a pet consuming the feeds receives quantities of ivermectin sufficient to establish and maintain substantially constant concentrations of the drug in the pet's bloodstream. The feeds are produced by extrusion with addition of minor quantities of ivermectin so as to uniformly distribute the drug throughout the extruded product. Ivermectin levels of from about 2-1500 &mgr;g/kg of extruded feed are preferred.

Domesticated household pet food including maintenance amounts of ivermectin

The present invention relates to the preparation of orally administrable formulations of quinolone- or naphthyridonecarboxylic acids by mixing quinolone- or naphthyridonecarboxylic acids as such or in the form of their water-soluble salts or derivatives, preferably in the form of their aqueous salt solutions, with embonic acid as such or in the form of its water-soluble salts or derivatives, preferably in the form of its aqueous salt solutions, in the presence of an excipient, optionally in the presence of auxiliaries, when using dry mixtures in the presence of water, and optionally converting the mixture obtained into further ready-to-use forms.

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Overland Park, KS, United States of America

Francisco Cabrera