Merck + Co., Inc.

Merck Sharp + Dohme Corp.

Merck Sharp & Dohme De Espana Sa

Francisca Vicente

Gerald F Bills

Fernando Pelaez

Deborah L Zink

Maria T Diez

Jerrold M Liesch

Sandra A Morris

John R Thompson

James E Curotto

Angela Basilio

Sarah J Dreikorn

Janet C Onishi

Robert E Schwartz

Robert A Giacobbe

Wendy S Horn

Maria S Meinz

Stanley L Streicher

Angeles Cabello

Rosalind G Jenkins

Isabella Martin

Otto D Hensens

Sheo B Singh

David Brian Olsen

Michael A Goetz

Isabel Martin

Jon D Polishook

Jack L Smith

Gregory L Helms

Olga Genilloud

Myra B Kurtz

Richard K Jansson

Bruce W Burgess

Scott Knoble Smith

Julian Gorrochategui

Barnali Pramanik

Teresa Diez

The present invention relates to novel compounds of formulae (I) and (II) and pharmaceutically acceptable salts thereof that are useful in the treatment and/or prevention of human and animal bacterial infections and associated diseases and conditions; compositions containing such compounds; derivation of such compounds by fermentation and isolation, partial synthesis and total synthesis; methods of inhibiting bacterial growth; methods of treating, preventing or controlling bacterial infection; biologically pure cultures of bacterial strains from which such compounds may be produced; and processes for preparing compositions containing such compounds. 

Extracts from kibdelos porangium as antibacterial agents

There are disclosed novel compounds having the formula ##STR1## which exhibit antifungal activity.

Antifungal agents

There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.

Antifungal agent obtained from hormonema

Antifungal agent

There is disclosed a compound having the formula ##STR1## which is produced by the fungus, Arthrinium arundinis ATCC 74359, and exhibits antifungal activity.

Antifungal agent produced by arthrinium arundinis  ATCC 74359

A compound of the formula 1: ##STR1## is produced via fermentation of a fungal isolate ATCC no. 74235. The organism is included herein, as well as a process for production of the compound, a pharmaceutical composition and a method of treatment.

Antifungal compound and compositions containing the compound

New antibiotic eicosenoic acids and a method of producing it are described. The acids have been found to have antifungal properties.

Antibiotic eicosenoic acids

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Madrid, Spain

Francisca Vicente