Bristol-myers Squibb Compnay

Britsol-myers Squibb Company

Francis S Gibson

Purushotham Vemishetti

John L Dillon, Jr

Jianmei Wei

Rajeev S Bhide

Zhen-Wei Cai

Chiajen Lai

Lori Ann Spangler

David Kenneth Leahy

Ligang Qian

Stephanie Barbosa

Jaan A Pesti

Gerard Crispino

Luca Parlanti

Junying Fan

John E Thornton

Paul C Lobben

Zhongmin Xu

Robert P Discordia

Mourad Hamedi

Thomas L LaPorte

Jale Muslehiddinoglu

The invention relates to an improved process for preparing [(1R), 2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester of the formula:  Compound I has been shown to be useful for the treatment of certain types of cancer.

Process for the preparation of [(1R), 2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2, 1-F][1,2,4]triazin-6-yloxy]-1-methylethyl ester

The present invention relates to a process for preparing certain pyrrolotriazine compounds of the formulaand pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

Process for preparing certain pyrrolotriazine compounds

Process for synthesizing paclitaxel by treating baccatin III with a strong base in a solvent, adding an electrophile to the solution to form a 7-O-protected baccatin III derivative, reacting the 7-O-protected baccatin III derivative with a protected paclitaxel sidechain in a solvent such that the protected paclitaxel sidechain is coupled to the 13-hydroxyl of the 7-O-protected baccatin III, and subsequently deprotecting the protected paclitaxel sidechain and the 7-O protecting group to form paclitaxel, and intermediates used therein.

Synthesis of paclitaxel from baccatin III by protection of the 7-hydroxyl of baccatin III using a strong base and an electrophile

A process for the synthesis of paclitaxel from 10-deacetylbaccatin-III which is protected at the 7-position with a dialkylalkoxysilyl protecting group having the formula &mdash;Si(R),(OR&prime;).

Semi-synthesis of paclitaxel using dialkyldichlorosilanes

Disclosed are crystalline complexes of baccatin III with imidazole, 2-methylimidazole or isopropanol, which are useful for isolating baccatin III from plant tissue cell culture and plant extracts containing baccatin Ill.

Crystalline complexes of baccatin III with imidazole, 2-methylimidazole or isopropanol

Synthesis of paclitaxel from baccatin III by protection of the

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Dayton, NJ, United States of America

Francis S Gibson