Centre National De La Recherche Scientifique

Henkel Kommanditgesellschaft Auf Aktien

Bioalliance Pharma Sa

Laboratoire Des Stallergenes

Adir & Cie

Francis Puisieux

Hatem Fessi

Jean-Philippe Devissaguet

Serge Stainmesse

Dominique Duchene

Patrick Couvreur

Alain Le Ridant

Curt Thies

Monique Seiller

Jean-Louis Grossiord

Catherine Le Hen-Ferrenbach

Tran X Thao

Liliane Roblot-Treupel

Isabelle Millet-Genin

Antony Coleman

Mohamed Skiba

Denis Wouessidjewe

Airton Monza Da Silveira

Armelle Magnet

Isabelle Terrisse

Frederic Bonte

Michel Dehan

Gilles Ponchel

Jean-Phillppe Devissaguet

Christiane C Taupin

Curt Theis

Curt Fessi

Nanoparticles containing at least one active ingredient including at least one polymer, preferably a poly(alkylcyanoacrylate), in which the alkyl group, linear or branched, contains from 1 to 12 carbon atoms, and of at least one compound able to complex said active ingredient. The invention also concerns the method for preparing these nanoparticles.

Nanoparticles comprising at least one polymer and at least one compound able to complex one or more active ingredients

Preparation and use of novel cyclodextrin-based dispersible colloidal

Process for the production of multiple w/o/w emulsions

In the method for combining with liposomes heterogeneous substances contained in a mixture, in particular, allergenic substances such as allergens and/or allergenic extracts, contained in an allergenic preparation, by adsorption on the surface of, and/or incorporation in, liposomes which comprise cholesterol, a phospholipid and/or at least one ionic lipid which gives the liposome a positive or negative charge, the liposome or its constituents are combined with the mixture of heterogeneous substances, the pH of the entire combination being higher or lower than the isoelectric point ip of the substances contained in the mixture, depending on whether the ionic lipid is charged positively or negatively respectively.

Method for combining a mixture of heterogeneous substances with liposomes

Dispersible colloidal systems of amphiphilic lipids in the form of oligolamellar liposomes of submicron dimensions are prepared by combining a first liquid phase consisting essentially of a solution of the lipids with a greater amount of a second liquid phase consisting essentially of water. The solvent for the first liquid phase is miscible in all proportions with water. If desired, the first liquid phase may also contain a substance A in solution therewith, such as cholesterol. An additional substance B, which is a biologically active substance, may be present in the first phase if it is lipophilic, and in the second phase if it is hydrophilic.

Process for the preparation of dispersible colloidal systems of

The Process according to the invention comprises:

Process for the preparation of dispersible colloidal systems of a

The process according to the invention comprises: (1) the preparation of a liquid phase consisting essentially of a solution of the substance in a solvent or in a mixture of solvents to which may be added one or more surfactants, (2) the preparation of a second liquid phase consisting essentially of a non-solvent or a mixture of non-solvents for the substance and to which may be added one or more surfactants, the non-solvent or the mixture of non-solvents for the substance being miscible in all proportions with the solvent or the mixture of solvents for the substance, (3) the addition of one of the liquid phases prepared in (1) or (2) to the other with moderate stirring so as to produce a colloidal suspension of nanoparticles of the substance, and (4) is desired, the removal of all or part of the solvent or the mixture of solvents for the substance and of the non-solvent or the mixture of non-solvents for the substance so as to produce a colloidal suspension of nanoparticles of the desired concentration or to produce a powder of nanoparticles.

The process according to the invention comprises:

Process for the preparaton of dispersible colloidal systems of a

New artificial surfactants composed of dipalmitoylphosphatidylcholine, distearoylphosphatidylcholine and soya lecithin and pharmaceutical compositions containing them, which can be used to replace deficient endogenous pulmonary surfactant.

Artificial surfactants, pharmaceutical compositions containing them and

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Maisons Alfort, France

Francis Puisieux