Mesoblast International Sarl

Other

Osiris Therapeutics, Inc.

Francis Peter Barry

David Jordan Fink

Arnold I Caplan

Robert Deans

J Mary Murphy

Annemarie Moseley

Scott Philip Bruder

Daniel R Marshak

Sudhakar Kadiyala

Randell G Young

Lanfranco Callegaro

James S Burns

Luis A Solchaga

Victor M Goldberg

Josephine Mary Murphy

Giovanni Abatangelo

Roland Moskowitz

Jung U Yoo

A method of repairing and/or stabilizing a joint by administering mesenchymal stem cells to the joint. Such a method provides for the regeneration of cartilaginous tissue in the joint, including meniscal tissue.

Joint repair using mesenchymal stem cells

For repair of cartilage damaged as part of the degenerative effects of osteoarthritis, the inventors have found that the human mesenchymal stem cell approach makes it possible to: (1) regenerate both shallow cartilage chondral defects and full thickness cartilage defects (osteochondral lesions); (2) broaden the suitable clinical population to routinely include middle-aged patients; (3) eliminate the use of autologous tissue grafts (mature cartilage and the periosteal covering) to repair an articular cartilage injury; (4) regenerate other types of injured cartilage such as patellar and spinal disk cartilage; (5) regenerate articular joint cartilage in older patients with osteoarthritis; and (6) form new cartilage and subchondral bone which fully integrate into the adjacent normal tissue.

Osteoarthritis cartilage regeneration

Biological material for the repair of connective tissue defects comprising mesenchymal stem cells and hyaluronic acid derivative

Growing community of inventors

Baltimore, MD, United States of America

Francis Peter Barry