Bristol-myers Squibb Compnay

E. R. Squibb Sons, Inc.

Francis N Ferrara

Karnail S Atwal

Saleem Ahmad

Philip D Stein

Charles Z Ding

David L Green

John E Lloyd

Gary J Grover

Lawrnce G Hamann

Compounds having the formula (I), and pharmaceutically acceptable salts thereof,are useful for modulating mitochondrial FFATPase activity and treating ischemic conditions including myocardial infarction, congestive heart failure, and cardiac arrhythmias.

(1-phenyl-2-heteoaryl)ethyl-guanidine compounds as inhibitors of mitochondrial F1F0 ATP hydrolase

Lactam derivatives as antiarrhythmic agents

Tetralone derivatives of the formula ##STR1## where R.sup.1 is halo, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, (aryl)alkenyl, (aryl)alkynyl, alkoxy, O-alkenyl, O-aryl, O-alkyl(heterocyclo), COO-alkyl,alkanoyl, CO-amino, CO-substituted amino, alkyl-CO-amino, alkyl-CO-substituted amino, NHCO-alkyl, NHCO-aryl, NHCO-alkyl(heterocyclo), N(alkyl)CO-alkyl, N(alkyl)CO-aryl, N(alkyl)CO-heterocyclo, N(alkyl)CO-alkyl(heterocyclo);

Tetralone derivatives as antiarrhythmic agents

Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein X is a single bond, O, CO, S, NH or N(lower alkyl); Y is O, S or NCN; and R.sup.1 to R.sup.5' are as defined herein. These compounds have potassium channel activating activity and are useful, therefore for example, as cardiovascular agents.

Aryl urea and related compounds

Novel compounds having potassium channel activating activity and useful, for example, as antiischemic agents are disclosed. These compounds have the general formula ##STR1## wherein A is ##STR2## or a single bond to complete an indoline nucleus; X is --O--, --S-- or --NCN; and the R groups are as defined herein.

Aminocarbonyl (thiocarbonyl) and cyanoguanidine derivatives of quinoline

Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein R.sup.1 to R.sup.4 and n are as defined herein and X is O, S or NCN. These compounds have potassium channel opening activity and are useful, therefore for example, as cardiovascular agents.

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Martinsville, NJ, United States of America

Francis N Ferrara