Novapharme

Univablot

Francis Lepage

Bernard M Hublot

Jacques N Astoin

Jean-Pierre M Fromantin

The invention relates to a compound useful for treating epilepsy selected from the compounds of the general formula: ##STR1## in which R.sub.1 is C.sub.1 -C.sub.4 alkyl,

N(pyrazol-3-yl) benzamides and pharmaceutical compositions

The object of the invention is heterocyclic compounds of general formula (I) endowed with anticonvulsant activity: ##STR1## in which Y is selected from --O--, --S-- and ##STR2## R.sub.4 being H or optionally substituted alkyl, acyl or benzyl, Z is selected from the groups --CO--N(R.sub.6)--,--NH--CO--CH.dbd.CH-- and --N(R.sub.6)--CO, R.sub.6 being H or alkyl;

3-Isoxazoyl derivatives endowed with anticonvulsant activity, procedure

The object of the invention are anticonvulsant heterocyclic compounds of general formula: ##STR1## in which R.sub.1 and R.sub.2 is each selected from C.sub.1 -C.sub.4 alkyl, phenyl, benzyl, trifluoromethyl or halogen, R.sub.3 is selected from hydrogen, hydroxy, C.sub.1 -C.sub.4 alkyl or alkoxy, R.sub.4, in position 3 or 5, is selected from hydrogen, trifluoromethyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkyl, or C.sub.1 -C.sub.4 hydroxyalkyl,

Novel isoxazole and isoxazoline compounds with anticonvulsant activity

Antiulcer amino-benzimidazole compounds substituted on the nitrogen; these compounds correspond to the following general formula: ##STR1## in which the various substituents are defined hereinbelow.

Antiulcer benzimidazoles

The present invention relates to oxime ethers of the general formula I ##STR1## R.sub.2 being a pyridyl radical. The invention also relates to processes for the preparation of oxime ethers of general formula I. The compounds according to the invention may be used as medicaments particularly for their spasmolytic and anti-histamine action.

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Creteil, France

Francis Lepage