Parke-davis Company

Warner-lambert Company

Warner Lambert LLC

Parke, David & Company

Francis John Tinney

Ernest D Nicolaides

David T Connor

Joseph Thomas Repine

James S Kaltenbronn

Roderick J Sorenson

Wiaczeslaw A Cetenko

Elizabeth Ann Lunney

Alfred Campbell

Joseph J Kerbleski

James P Hudspeth

W Howard Roark

Ila Sircar

John C Hodges

Annette M Doherty

Gary Louis Bolton

Thomas F Mich

William Howard Roark

James C French

Daniele Marie Leonard

Michael Andrew Stier

Donald John Hupe

Peter W Woo

Tomi Sawyer

Eugene Leroy Wittle

Judith Sebolt-Leopold

Mildred Catherine Rebstock

Marland Paul Hutt

Richard Gowan

Thomas F Mick

Dana E DeJohn

Inhibitors of protein:farnesyl transferase enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in controlling tissue proliferative diseases, including cancer and restenosis.

Substituted tetra- and pentapeptide inhibitors of protein: farnesyl

The invention concerns novel renin-inhibitory peptides which are useful for treating renin-assocated hypertension, hyperaldosteronism, and congestive heart failure. Processes for preparing the peptides, compositions containing them and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension or hyperaldosteronism.

Renin inhibitors IV

The invention concerns novel renin-inhibitory peptides which are useful for treating renin associated hypertension and for treating hyperaldosteronism. Novel intermediates, processes for preparing both the intermediates and the novel peptides, pharmaceutical compositions, and methods of treatment are included.

Renin inhibitors

Modified oxytocin-vasopressin di- or tri-peptides wherein an amide group is replaced by a group selected from ##STR1## --CH.sub.2 NH--, --CH.sub.2 O--, --CH.sub.2 S--, --CH.sub.2 SO--, --CH.sub.2 SO.sub.2 --, --CH.sub.2 CH.sub.2 -- and --CH.dbd.CH-- are described as well as methods for their manufacture, pharmaceutical compositions and methods for treatment, especially of cognitive disorders, depression, morphine dependency and parkinsonism by adjunctive therapy.

Modified tripeptides

Oxo-pyrido[1,2-a]thienopyrimidine compounds, salts thereof, methods of production, intermediates in their production, pharmaceutical compositions containing said compounds and methods for treating allergies using said compositions are disclosed.

Certain 2-pyridylamino-3-thiophene carboxylic acid derivatives

Dihydro-oxo-pyrido[1,2-a]thienopyrimidine compounds

Oxo-pyrido[1,2-a]thienopyrimidine compounds and methods for their

A new decapeptide having the formula, pGlu-His-Trp-Ser-Tyr-Gly-Leu-NO.sub.2 Arg-Pro-Gly(NH.sub.2); salts thereof; production thereof by reacting pGlu-His-Trp-Ser-Tyr(N.sub.3) with Gly-Leu-NO.sub.2 Arg-Pro-Gly(NH.sub.2), by reacting pGlu-His-Trp-Ser-Tyr-Gly(N.sub.3) with Leu-NO.sub.2 Arg-Pro-Gly(NH.sub.2), or by reacting pGlu-His-Trp-Ser-Tyr-Gly-Leu(N.sub.3) with NO.sub.2 Arg-Pro-Gly(NH.sub.2); certain peptide intermediates and their salts used in the production thereof; and the use thereof in the preparation of luteinizing hormone releasing factor.

Pyroglutamyl-histidyl-tryptophanyl-seryl-tyrosyl hydrazides

New nonapeptides having the formula R-Trp-Ser(benzyl)-Tyr(benzyl)-D-Phe-Leu-Arg(X)-Pro-Gly-Y wherein X is a protective group, R is pGlu, protected His(benzyl), protected Ser(benzyl) or protected Cys(benzyl), and Y is lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino.

Nonapeptides and methods for their production

New octapeptides having the formula X-R.sup.1 -Trp-Ser(benzyl)-Tyr(benzyl)-R.sup.2 -Leu-Arg(R)-Pro-R.sup.3 -Y wherein X is a protective group, R is hydrogen or a protective group, R.sup.1 is a single bond, Gln, D-Leu or D-Val, R.sup.2 is D-Phe or D-Ala, R.sup.3 is a single bond or Gly and Y is lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino.

Octapeptides and methods for their production

New octapeptides having the formula X-R-Pro-His(benzyl)-His(benzyl)-R.sup.1 -Trp-D-Ala-Y wherein X is a protective group, R is Pro or Gln; R.sup.1 is Tyr(benzyl)-Ser(benzyl) or Ser(benzyl)-Pro and Y is lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino.

New heptapeptides having the formula X-Ser(benzyl)-Tyr(benzyl)-Phe-Leu-Arg(R)-Pro-Gly-Y wherein X is a protective group, R is a protective group and Y is lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino.

Heptapeptides and methods for their production

New hexapeptides having the formula X-Trp-His-(benzyl)-Ser(benzyl)-Tyr(benzyl)-Pro-Ala-Y wherein X is t-butoxycarbonyl or benzyloxycarbonyl and Y is lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino.

Hexapeptides and methods for their production

New heptapeptides having the formula X-R-His(benzyl)-His(benzyl)--R.sup.1 --R.sup.2 --Trp--Ala--Y wherein X is a protective group, R is Pro or Gln; R.sup.1 and R.sup.2 are Ser(benzyl) or Tyr(benzyl) and Y is lower alkoxy, amino, lower alkylamino or di(lower alkyl)-amino.

New heptapeptides and methods for their production

New hexapeptides having the formula X-R-Trp-His(benzyl)-Tyr(benzyl)-Ser(benzyl)-R.sup.1 -Ala-Y wherein X is t-butoxycarbonyl or benzyloxycarbonyl, R is a single bond, His, His(benzyl) or Gln; R.sup.1 is a single bond or Pro and Y is lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino with the proviso that the total number of amino acid units when R and R.sup.1 are combined is one.

Growing community of inventors

Ann Arbor, MI, United States of America

Francis John Tinney