Gropep Pty, Ltd.

Gropep Limited

Mayo Foundation for Medical Education and Research

Francis John Ballard

Geoffrey Leonard Francis

Geoffrey Owen Regester

David Andrew Belford

Leanna Christine Read

John C Wallace

Cheryl A Conover

Sundeep Khosla

Julian R Wells

Peter M Tapley

Geoffrey Welsford Smithers

Mary-Louise Rogers

Christopher J Bagley

The invention relates to pharmaceutical or veterinary compositions for the treatment of surface wounds; pharmaceutical or veterinary compositions for the treatment of gastrointestinal injuries, diseases or ulcers; methods of treating surface wounds in animals, including humans; and methods for the treatment of gastrointestinal injuries, diseases or ulcers which compositions and methods include compositions of milk product extracts including growth factors with basic to approximately neutral isoelectric points.

Growth-promoting agent

A substantially pure complex including IGFIIE polypeptide and IGFBP2 polypeptide is described. Methods for treating an osteoporosis patient and targeting a compound to the skeletal extracellular matrix of a patient are also described.

Treatment of osteoporosis

The invention provides a process for preparing a plurality of modified milk growth factors which process includes: providing a milk product extract including a plurality of milk growth factors having basic to approximately neutral isoelectric points and a source of acid; subjecting the milk product extract to transient acidification utilising the acid source; and isolating a plurality of modified milk growth factors from the transiently acidified milk product extract. Also provided are growth promoting compositions, cell culture compositions, and pharmaceutical or veterinary compositions for the treatment of surface wounds, gastrointestinal injuries, diseases or ulcers, each including a plurality of modified milk growth factors having isoelectric points above approximately 6.0 and molecular weights in the range of approximately 5000 to 30.000, the milk growth factors being modified by transient acidification.

Modified milk growth factor

Milk protein mixture for promoting growth of animal cells or treating

A method for the treatment of disorders in gut function in animals including humans, which method includes administering to a patient to be treated an effective amount of a mammalian insulin-like growth factor-I (IGF-I) or a peptide analogue thereof.

Method for treating intestinal diseases

The invention provides peptide analogues of insulin-like growth factor-1 (IGF-1) or factor-2 (IGF-2). The peptide analogues of IGF-1 have at least the glutamic acid residue at position 3 replaced by another amino acid. The peptide analogues of IGF-2 are replaced at position 5 or 6 with another amino acid.

Peptide analogs of insulin-like growth factor II

Peptide analogues of insulin-like growth factor 1 (IGF-1) or factor 2

Growth factor

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Kensington, Australia

Francis John Ballard