Lakehead University

Chinook Biomedical Inc.

Lakehead University Economic Development and Innovation Office

Francis Hane

Mitchell Albert

Yurii Shepelytskyi

Tao Li

Yurli Shepelytskyi

Igor Zavislyak

Described herein is a method for detecting changes in blood flow in a tissue portion and/or body portion of an individual. The method can be used to detect any sort of pathology, trauma or insult which results in blood flow change. Specifically, this method uses hyperpolarized 129Xe MRI to detect xenon perfusion changes in tissues such as brain tissue that corresponds to changes in blood flow, for example, changes caused by functional activities of the brain or regions of the body where blood flow may be compromised.

Method to detect brain functional activities using hyperpolarized 129Xe MR

Described herein is a ventilator that is able to use readily available, low cost on/off non-proportional solenoid valves to provide adequate ventilatory control to patients by achieving rapid Airway Pressure while precisely regulating the Airway Pressure.

Method of pressure control in a mechanical ventilator with non-proportional solenoid valves

Xenon based biosensors have the potential to detect and localize biomarkers associated with a wide variety of diseases. The development and nuclear magnetic resonance (NMR) characterization of cage molecules which encapsulate hyperpolarized xenon is imperative for the development of these xenon biosensors. We acquiredXe NMR spectra, and magnetic resonance images and a HyperCEST saturation map of cucurbituril (CB6) in whole bovine blood. We observed a mean HyperCEST depletion of 84% (n=5) at a concentration of 5 mM and 74% at 2.5 mM. Additionally, we collected these data using a pulsed HyperCEST saturation pre-pulse train with a SAR of 0.025 W/kg which will minimize any potential RF heating in animal or human tissue.

In vivo detection of a xenon-binding cage molecule

Growing community of inventors

Thunder Bay, Canada

Francis Hane