Amgen Inc.

Medarex Inc.

Amgen Fremont Inc.

Other

E. R. Squibb Sons, Inc.

Francis Hall Martin

Krisztina M Zsebo

Robert A Bosselman

Sidney V Suggs

Haichun Huang

Alison Witte

Brian C Varnum

Xueming Qian

Chris Vezina

Gary Elliott

Rachel Yabkowitz

Catherine L Farrell

Kenneth William Walker

Jose Corvalan

William James Boyle

Shaw-Fen Sylvia Hu

Leslie Phillip Miranda

C Geoffrey Davis

John Kevin Sullivan

Hung Q Nguyen

Colin Victor Gegg, Jr

Beverly S Adler

Joseph G McGivern

Taruna Arora Khare

Wenyan Shen

Tsutomu Arakawa

Dimitry Michael Danilenko

Nobuyuki Itoh

Geoffrey C Davis

Chen Zhou

Gary Elliot

Geoffrey Davis

Jose R Corvalan

Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.

Therapeutic human anti-IL-1R1 monoclonal antibody

Antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are described. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are described.

Methods for treating bone loss with antibodies to OPGL

Compositions comprising polynucleotides encoding heavy and light chains of antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of making such antibodies are described.

Polynucleotides encoding heavy and light chains of antibodies to OPGL

Disclosed is a composition of matter comprising a ShK toxin peptide analog, and in some embodiments, a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises the composition and a pharmaceutically acceptable carrier. Also disclosed are DNAs encoding the inventive composition of matter, an expression vector comprising the DNA, and host cells comprising the expression vector. Methods of treating an autoimmune disorder and of preventing or mitigating a relapse of a symptom of multiple sclerosis are also disclosed.

DNA encoding chimeric toxin peptide fusion proteins and vectors and mammalian cells for recombinant expression

Disclosed is a composition of matter comprising an OSK1 peptide analog, and in some embodiments, a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises the composition and a pharmaceutically acceptable carrier. Also disclosed are DNAs encoding the inventive composition of matter, an expression vector comprising the DNA, and host cells comprising the expression vector. Methods of treating an autoimmune disorder and of preventing or mitigating a relapse of a symptom of multiple sclerosis are also disclosed.

Methods of using conjugated toxin peptide therapeutic agents

The invention provides methods for screening multimeric antibodies produced by mammalian cells to find those that exhibit a biological function. The methods can be used to screen large numbers of antibodies, which may be cell surface, secreted, or intracellular antibodies. Antibodies can be screened to find those that bind antigen more avidly or those that compete with a ligand that binds to the antigen for binding. Any biological function that can be tested in vitro can be used to screen the antibodies. Nucleic acids encoding the antibodies that exhibit the biological function can be obtained in a number of ways.

Methods for identifying functional antibodies

Conjugated toxin peptide therapeutic agents

Therapeutic human anti-IL1-R1 monoclonal antibody

Antibodies to OPGL

Novel stem cell factors, oligonucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders involving blood cells are also disclosed.

SCF antibody compositions and methods of using the same

Method for increasing hematopoietic progenitor cells by stem cell factor

Method of stimulating growth of melanocyte cells by administering stem cell factor

Growing community of inventors

Newbury Park, CA, United States of America

Francis Hall Martin