Biomerieux, Inc.

Biomerieux Sa

Francis Garnier

Bernard F Mandrand

Patrick Broyer

Corinne Moustrou

Pierre Imbaud

Nicolas Spinelli

Aude-Emmanuelle Navarro

Carole Chaix-Bauvais

Hugues Brisset

The invention relates to bi-functionalised metallocenes of general formula (I) where Me=a transition metal, preferably chosen from Fe, Ru and Os, Y and Z, when identical are selected from &#x2014;(CH)&#x2014;O&#x2014;, (CH)&#x2014;O&#x2014;[(CH)&#x2014;O]&#x2014; and &#x2014;(CH)&#x2014;CONH&#x2014;(CH)&#x2014;O&#x2014;, or Y=&#x2014;(CH)&#x2014;NH&#x2014; and Z=&#x2014;(CH)&#x2014;COO&#x2014;,=a whole number from 3 to 6 inclusive, p=a whole number from 1 to 4 inclusive, q=a whole number from 0 to 2 inclusive, r=a whole number from 0 to 2 inclusive, s=a whole number from 2 to 5 inclusive, t=a whole number from 3 to 6 inclusive, R and R'=H atoms or are protective groups used in oligonucleotide and peptide synthesis, where at least one of R or R&#x2032; is protective group used in oligonucleotide and peptide synthesis and R and R&#x2032; are as defined below: (i) when Z and Y are selected from (CH)&#x2014;O&#x2014;, &#x2014;(CH)&#x2014;O&#x2014;[(CH)&#x2014;O]&#x2014; and &#x2014;(CH)&#x2014;CONH&#x2014;(CH)&#x2014;O&#x2014;, then R and R&#x2032; are protective groups used in oligonucleotide synthesis and R is a group which can leave a free OH group after deprotection, preferably a photolabile group such as monomethroxythoxytrityl, dimethoxytrityl, t-butyldimethylsilyl, acetyl or trifluroacetyl, and R&#x2032; is a phosphorylated group which can react with a free OH, preferably a phosphodiester, phosphoramidite or H-phosphonate and (ii) when Y=&#x2014;(CH)&#x2014;NH&#x2014; and Z=&#x2014;(CH)&#x2014;COO&#x2014;, then R is a protective group used in the synthesis of peptides and is an amino-protecting group, preferably 9-fluorenyloxycarbonyl, t-butoxycarbonyl or benzyloxycarbonyl and R&#x2032;=H. The above is applied in marking.

Bi-functional metallocenes, preparation process and use in the labeling or biological molecules

This invention concerns a valve (), with at least one channel () running through it, allowing a fluid (F) to be directed by transfer means within a device (), the device () featuring at least one face (), possibly flat, the valve () consisting of a film (or), flexible and/or which can be deformed, fixed on all or part of the face () of said device (), and a film actuator (), which enables said valve () to be activated or deactivated, this actuator consisting of an electrical power source. It also consists of a test sample card () equipped with at least one valve (), and a process for actuating the valve (), as described above. The invention is particularly applicable in the field of diagnosis.

Valves activated by electrically active polymers or by shape-memory materials, device containing same and method for using same

There are electrically conductive, electroactive functionalized conjugated polymers having formula (I):

Electrically conductive electroactive functionalized conjugated polymers, and uses thereof

Electrically conductive electroactive functionalized conjugated

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Champigny sur Marne, France

Francis Garnier