Leland Stanford Junior University

Other

University of Washington

Theseus Imaging, Corp.

Francis G Blankenberg

H William Strauss

Jonathan F Tait

Peter D Katsikis

Allan M Green

Sandip Biswal

Neil Steinmetz

Derek Holman

Strauss H W

Methods of detecting diagnostic biomarkers on cancer-derived extracellular vesicles such as exosomes by mid-infrared spectroscopy are provided. In particular, methods of detecting ovarian cancer by spectral fingerprint analysis of molecular vibrational spectroscopic markers on individual or subpopulations of extracellular vesicles are disclosed.

Molecular vibrational spectroscopic markers for detection of cancer

Methods are provided for treating a subject with cancer, with a therapeutic dose of annexin V to the subject.

Use of annexin v as a method to block tumor induced immunosuppression of the innate immune response

Methods are provided for treating a subject with for an intracellular pathogen infection, by administering an agent that masks or otherwise blocks phosphatidylserine on the pathogen cell surface.

Use of annexin V to reduce the spread of intracellular pathogens

Briefly described, embodiments of the present disclosure relate to methods and compositions for imaging pain and/or stress in a subject and methods and compositions for treating associated conditions. In particular, the present disclosure relates to the use of labeled compounds to provide objective diagnosis of pain and/or stress, for imaging regions associated with pain and/or stress, and for treating pain in a subject.

Compositions and methods for imaging pain and stress in vivo

A method of imaging apoptosis in vivo, using radiolabeled annexin, is described.

Method of imaging cell death in vivo

A method of imaging apoptosis in vivo, using radiolabeled annexin, is described. Methods for tumor radiotherapy are also provided.

Growing community of inventors

Menlo Park, CA, United States of America

Francis G Blankenberg