General Electric Company

Francis Edward Pavan-Woolfe

Michael John Gerdes

Ali Can

Xiaodong Tao

Musodiq O Bello

Roshni Bhagalia

Techniques for removing image autoflourescence from fluorescently stained biological images are provided herein. The techniques utilize non-negative matrix factorization that may constrain mixing coefficients to be non-negative. The probability of convergence to local minima is reduced by using smoothness constraints. The non-negative matrix factorization algorithm provides the advantage of removing both dark current and autofluorescence.

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New Haven, CT, United States of America

Francis Edward Pavan-Woolfe