Beecham Group Plc

Smithkline Beecham Corporation

Beecham Group P.l.c. of Beecham House

Beecham Gropup P.l.c.

Francis D King

Laramie Mary Gaster

Michael S Hadley

Paul Adrian Wyman

Keith Raymond Mulholland

Karen A Joiner

Rodney C Young

Roger T Martin

Alberto J Kaumann

Shirley Katherine Rahman

Graham Francis Joiner

Ian Thomson Forbes

Eric A Watts

Steven Mark Bromidge

Gareth J Sanger

Guy Anthony Kennett

Peter Ham

Kay A Wardle

Gordon S Baxter

Graham Elgin Jones

David Thomas Davies

Mythily Vimal

Francis E Blaney

Alberto J Kauman

Angela Moghe

Thomas W Ramsay

Sulphonamide derivatives, process for their preparation, and their use as medicaments

Sulphonamide compounds according to formula (I) or pharmaceutically acceptable salts thereof:

Sulphonamide derivatives and their use in the treatment of CNS disorders

Spiro piperidine derivatives as 5HT1D receptor antagonists

Benzopyran, benzothiopyran and benzofuran derivatives as 5-HT4

Compounds of formula (I) and pharmaceutically acceptable salts thereof, and the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof:

5-HT.sub.4 receptor antagonists useful in the treatment of

Tetracyclic spiro compounds as 5HT.sub.1B receptor antagonists

Tetracyclic spiro compounds, process for their preparation and their use

Pyridil carboxamides as 5HT2B/2C receptor antagonists

The use of a compound of formula (I) or a pharmaceutically acceptable salt thereof for the treatment of artrial arrhythmia, stroke or CNS disorders

5-HT4 receptor antagonists

Use of a compound of general formula (I): ##STR1## wherein R.sup.1 represents hydrogen, halogen, trifluoromethyl, nitro, hydroxy, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, arylC.sub.1-6 alkoxy, --CO.sub.2 R.sup.4, --(CH.sub.2).sub.n CN, --(CH.sub.2).sub.n CONR.sup.5 R.sup.6, --(CH.sub.2).sub.n SO.sub.2 NR.sup.5 R.sup.6, C.sub.1-6 alkanoylamino(CH.sub.2).sub.n, or C.sub.1-6 alkylsulphonylamino(CH.sub.2).sub.n ;

Medicaments 1,2,3,4-tetrahydrocarbazoles and 5-HT.sub.1 agonist use

Heterocyclic biphenylylamides useful as 5HT1D antagonists

Compounds of formula (I), or pharmaceutically acceptable salts thereof are provided: ##STR1## in which X.sub.1 --(CH.sub.2).sub.x --X.sub.2 forms a 5-7 membered ring wherein:

Heteroaryl compounds used as pharmaceuticals

5-HT.sub.4 receptor antagonist

Heterocyclic-esters or -amides used as 5-HT.sub.4 receptor antagonists

Growing community of inventors

Harlow, United Kingdom

Francis D King