University of California

Liposome Technology, Inc.

Celator Pharmaceuticals, Inc.

Molecular Express, Inc.

Francis C Szoka

Mark Eamon Hayes

Charles O Noble

Alexander Marson

Theodore Lee Roth

Douglas S Watson

Gary Fujii

M Jane Ehrke

Eric Mayhew

Fred C Olson

Kenneth Mace

David-Huy Nhu Nguyen

Daniel Goodman

The disclosure provides compositions and methods for modifying a target nucleic acid. In some embodiments, a composition can include a targetable nuclease, a DNA-binding protein, and a donor template comprising a homology directed repair (HDR) template and one or more DNA-binding protein target sequences. In some embodiments, a composition can include a Cas protein, one or more single guide RNAs (sgRNAs), and an anionic polymer.

Compositions and methods for modifying a target nucleic acid

A method for enhancing the therapeutic effectiveness of adriamycin, in the treatment of cancer, is disclosed. Liposomes containing coentrapped adriamycin and a secondary compound effective to reduce the toxicity of adriamycin or enhance the induction by adriamycin of the tumoricidal activity of host lymphoid cells, such as lipopolysaccharide, are administered parenterally in a therapeutically effective dose. In another aspect, macrophages stimulated in vivo with liposomes containing entrapped liposomes are exposed to an immunostimulator, for enhanced tumoricidal activity. Also disclosed are liposome compositions containing coentrapped adriamycin and an immunostimulator.

Liposome drug delivery method and composition

Growing community of inventors

Oakland, CA, United States of America

Francis C Szoka