Aventis Pharma S.a.

Sanofi

Rhone-poulenc Rorer S.a.

Centelion

Other

Gencell, S.a.

Sanofi-aventis

Rhone-poulenc Biochimie, Et Al.

Francis Blanche

Beatrice Cameron

Denis Thibaut

Joel Crouzet

Laurent Debussche

Tarik Dabdoubi

Béatrice Cameron

Vincent Mikol

Nicolas Baurin

Jo&euml;l Crouzet

Veronique Blanc

Patricia Lacroix

Nathalie Jacques

Valerie De Crecy-Lagard

Monique Zagorec

B&eacute;atrice Cameron

Alain Famechon

Hervé Bouchard

Laurent Pradier

Marc Duchesne

Jean-Claude Barriere

Ercole Rao

Christian Lange

Jean-Marc Paris

Gilles Dutruc-Rosset

Jochen Kruip

Carsten Corvey

Martin Lorenz

Christian Engel

Ingo Focken

Thomas Langer

Katja Kroll

Herve Bouchard

Catherine Prades

Corentin Herbert

Magali Mathieu

Vincent Thuillier

Françoise Bono

Alexey Rak

Stéphanie Decary

Paul Ferrari

Yi Shi

Pierre-Francois Berne

Souad Naimi

Jean-Marc Guillaume

Nathalie Bamas-Jacques

Peter Wonerow

Lucia Ferrero

Shian-Jiun Shih

Mark Nesbit

Marc Trombe

Sylvie Sordello

Peter Florian

V&eacute;ronique Blanc

Michel Couder

Jean-Pascal Herault

Pierre Fons

Elisabeth Remy

Sophie Levy Schil

Anne Barbot

Manoel Nunes

Yves Baudat

Anne-Marie LeFebvre

Celine Nicolazzi

Céline Nicolazzi

Frederique Dol-Gleizes

Ana Merino-Trigo

Véronique Blanc

Anne-Marie Lefebvre

Pierre-François Berne

Thierry Guillemin

David Gaillac

Nicolas Maestrali

Disclosed are antibodies which bind human andCEACAM5 proteins, as well as isolated nucleic acids, vectors and host cells comprising a sequence encoding the antibodies. Also disclosed are immunoconjugates comprising the antibodies conjugated or linked to a growth-inhibitory agent, and pharmaceutical compositions comprising the antibodies or immunoconjugates of the invention. The antibodies or immunoconjugates are used for the treatment of cancer or for diagnostic purposes.

Anti-CEACAM5 antibodies and uses thereof

Antibodies are provided which bind human andCEACAM5 proteins, as well as isolated nucleic acids, vectors and host cells comprising a sequence encoding the antibodies. Also provided are immunoconjugates comprising the antibodies conjugated or linked to a growth-inhibitory agent, and to pharmaceutical compositions comprising the antibodies, or immunoconjugates of the invention. The antibodies or immunoconjugates are used for the treatment of cancer or for diagnostic purposes.

Humanized antibodies specific to the protofibrillar form of the beta-amyloid peptide are provided. Methods of using antibodies specific to the protofibrillar form of the beta-amyloid peptide in the field of Alzheimer's disease are also provided.

Humanized antibodies specific to the protofibrillar form of the beta-amyloid peptide

Antibodies are provided which specifically bind human andlysosomal-associated membrane protein 1 (LAMP1) proteins and immunoconjugates comprising said antibodies conjugated or linked to a growth inhibitory agent. Pharmaceutical compositions comprising antibodies or immunoconjugates of the invention and use of the antibodies or immunoconjugates for the treatment of cancer are also provided, as well as LAMP1 antibodies, isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibodies and the use of said antibody as a diagnostic tool. The application further provides for the detection of LAMP1 gene amplification or gain in cancer cells leading to the determination if patients with cancer are likely to respond to anti-LAMP1 therapy. Anti-LAMP1 therapeutic agent for use for treating cancer in a patient harboring LAMP1 gene copy number gain in cancer cells is further provided.

Anti-LAMP1 antibodies and antibody drug conjugates, and uses thereof

The present invention discloses antibodies which bind human andCEACAM5 proteins, as well as isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibodies. The invention also discloses immunoconjugates comprising said antibodies conjugated or linked to a growth-inhibitory agent, and to pharmaceutical compositions comprising antibodies, or immunoconjugates of the invention. The antibodies or immunoconjugates of the invention are used for the treatment of cancer or for diagnostic purposes.

The present invention relates to a Robo1-Fc recombinant protein and to the use thereof for treating diseases in which a Slit protein is overexpressed, in particular cancer. The invention also relates to a composition including such a recombinant protein. Another aspect of the invention involves using a Robo1-Fc molecule as a diagnostic tool for detecting the overexpression of a molecule belonging to the Slit family in a patient.

Robo1-Fc fusion protein and use thereof for treating tumours

The present invention discloses novel antibodies that specifically bind to the human platelet membrane protein Glycoprotein VI (GPVI) and their monovalent fragments or derivatives. The antibodies of the invention are antibodies from hybridoma clone 390 and fragment antibodies thereof able to induce a GPVI depletion phenotype. These antibodies and Fab fragments are able to block collagen binding and thus preventing platelet activation by collagen. The invention also relates to hybridoma clones and expression plasmids for the production of disclosed antibodies and Fab fragments. The present invention further refers to the uses of monovalent antibody fragments to manufacture research, diagnostic and immunotherapeutic agents for the treatment of thrombosis and other vascular diseases. The invention also concerns a Fab bearing a molecule at the C-terminal extremity, as well as method for prevention of recognition of Fab by antibodies using such modified Fab. The invention concerns a method for prevention of platelet activation when an anti-GP VI Fab is used.

Antagonist antibodies and their fab fragments against GPVI and uses thereof

The present application relates to humanized antibodies specific to the protofibrillar form of the beta-amyloid peptide, and to the use of said antibodies in the field of Alzheimer's disease.

The invention relates to modified soluble FGF receptor Fc fusions comprising a fusion of a soluble fragment or domain of the FGF receptor part (targeting or binding moiety) with an Fc region of an immunoglobulin part (effector function moiety), having improved biological activity including ADCC/CDC activities, compositions containing them, and method of producing such modified soluble FGF receptor Fc fusion molecules.

Modified soluble FGF receptor Fc fusions method

Modified soluble FGF receptor Fc fusions with improved biological activity

The present invention relates to novel target double-stranded DNA sequences capable of interacting with a third strand and of forming a stable triple helix. The present invention also relates to a process for purifying a double-stranded DNA molecule, according to which a solution containing said DNA molecule is brought into contact with a third DNA strand capable of forming, by hybridization, a triple helix structure with a target double-stranded DNA sequence carried by said DNA molecule.

Processes for purifying and for detecting target double-stranded DNA sequences by triple helix interaction

Liquid or frozen compositions containing adenoviral-particles, comprising a buffer solution capable of maintaining the pH of the medium at slightly alkaline values, supplemented with glycerol and without addition of divalent metal cations or of alkali metal cations.

Composition intended for the preservation of infectious recombinant adenoviruses

The invention concerns methods for preparing pristinamycin IIA or IIB.

Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use

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Paris, France

Francis Blanche