E. R. Squibb Sons, Inc.

Francis A Sowinski

B Richard Vogt

Jerome L Moniot

Rita T Fox

A method is provided for preparing the optically active isomer [2R-[2.alpha.,3.alpha.,5(R*)]]-2,2'-[[5-[3-[(1,1-dimethylethyl)amino]-2-hy droxypropoxy]-1,2,3,4-tetrahydro-2,3-naphthalenediyl]bis(oxy)]bis-[N,N-dipr opylacetamide] having the structure ##STR1## which is useful as an antiarrhythmic agent.

Method for preparing the optically active isomer of

Novel 1,2,4-benzothiadiazines substituted by an oxo group in the 3-position and substituted in the 4-position with hydrogen, lower alkyl, amino-lower alkyl, mono- or di-lower alkyl amino-lower alkyl, or imino-lower alkyl, are useful as central nervous system depressants, and as diuretics.

1,2,4-Benzothiadiazines

Novel 1,2,4-benzothiadiazines substituted with an amino, alkylamino, or dialkylamino group in the 3-position are useful as central nervous system depressants and as diuretics.

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Edison, NJ, United States of America

Francis A Sowinski