The Cleveland Clinic Foundation

Autonomic Technologies, Inc.

Xii Medical, Inc.

Other

University of Akron

Kls Martin, Inc.

Osteosymbionics LLC

Francis A Papay

Anthony V Caparso

Carl Lance Boling

Ji-Feng Chen

Shengqiang Gao

Yang Liu

Jennifer Teng

Ryan Powell

Kelly B Emerton

Morgan Clyburn

Benjamin D Pless

Thomas S Johnston, Jr

Josh Nickols

Charles P Steiner

Cameron J Fordyce

Jennifer C Pinto

Klaus Kohler

Nicholas T Wilkins

Stefan Budac

Bryan P Byerman

Michael M Maierson

Mike Hardage

Jessie San

One aspect of the present disclosure relates to a system for treating obstructive sleep apnea in a subject. The system can include a power source and a neuromuscular stimulator in electrical communications with the power source. The neuromuscular stimulator can include a controller and at least one electrode. The controller can be configured to receive certain power and stimulation parameters associated with a therapy signal from the power source. The at least one electrode can be configured to deliver the therapy signal to a target tissue associated with control of a posterior base of the tongue of the subject.

System and method for treating obstructive sleep apnea

One aspect of the present disclosure relates to an endoscope for facilitating a medical procedure by creating an anatomic space in or adjacent a target bodily tissue to be imaged. The endoscope can comprise a flexible, elongate tubular member defining a central lumen and an expandable dissecting member coupled to a distal end of the tubular member. The tubular member can further include at least one imaging channel extending longitudinally therethrough. The at least one imaging channel can include a visualization system for conveying an image from the distal end of the tubular member to a user. The expandable dissecting member can define a channel in fluid communication with the central lumen of the tubular member. The expandable dissecting member can extend beyond the distal end of the tubular member.

Endoscope for tissue dissection and visualization

Neural stimulation is provided according to a closed loop algorithm to treat sleep disordered breathing (SOB), including obstructive sleep apnea (OSA). The closed loop algorithm is executed by a system comprising a processor (which can be within the neural stimulator). The closed loop algorithm includes monitoring physiological data (e.g., EMG data) recorded by a sensor implanted adjacent to an anterior lingual muscle; identifying a trigger within the physiological data, wherein the trigger is identified as a biomarker for a condition related to sleep (e.g., inspiration); and applying a rule-based classification (which can learn) to the trigger to determine whether one or more parameters of a stimulation should be altered based on the biomarker.

Systems and methods to improve sleep disordered breathing using closed-loop feedback

An intra-oral appliance to power and/or communicate with a neurostimulator is provided. The intra-oral appliance can include a teeth covering configured to fit over mandibular incisor, canine and/or premolar teeth of a human being and a remote controller in the form of a housing extending posteriorly from and operably connected to the teeth covering. The housing can include a power source, a coupling coil configured to transmit power to the neurostimulator and configured to receive power from an external charger, and electrical circuitry operably connected to the coupling coil and the power source.

Intra-oral appliances and systems

A system is provided for healing a wound. The system includes a flexible body, a therapeutic agent delivery mechanism, a suction mechanism, and a power source. The flexible body includes a cover film having oppositely disposed first and second surfaces that define a compartment. The compartment includes a first porous material, a second porous material, and at least one electrode disposed therein. The second porous material is disposed between the first porous material and the at least one electrode. The therapeutic agent delivery mechanism and the suction mechanism are fluidly connected to the compartment. The power source is in electrical communication with the at least one electrode.

System and method for wound healing

One aspect of the present disclosure relates to a system that can employ multi-modal imaging to provide an image with an enhanced resolution. In some instances, the multi-modal imaging can allow an operator to determine and control a tissue margin without the need for intra-operative tissue pathology. The system can include an imaging system that includes a gamma camera to detect a gamma image and an optical imaging modality to detect an optical image. The system can also include a display device to display an enhanced gamma image created based on a function of the optical image. The enhanced gamma image illustrates a characteristic of a disease in the field of view (e.g., a lymphatic pathway, a sentinel lymph node target, or a satellite disease state).

Systems and methods that use multi-modal imaging for enhanced resolution images

A maxillomandibular fixation (MMF) device having an arch bar with a plurality of spaced tabs and gaps, and further having apertured mounting plate members mounted onto the arch bar, each mounting plate member having a slot to receive a tab on the arch bar, whereby the mounting plate members may be repositioned laterally along the arch bar from one tab to another prior to affixing the MMF device to the maxilla or mandible of a patient in order to position the mounting plate members at locations where the underlying tooth root will not be damaged by insertion of a bone screw.

Maxillomandibular fixation devices

A surgical guide to facilitate delivery of a therapy delivery device into the pterygopalatine fossa of a subject includes a curvilinear body having a distal end portion, a proximal end portion, and an intermediate portion extending between the distal and proximal end portions. The proximal end portion is defined by oppositely disposed first and second surfaces. The proximal end portion and the intermediate portion define a longitudinal plane that extends between the proximal and distal end portions. The distal end portion has an arcuate configuration relative to the longitudinal plane and is defined by oppositely disposed third and fourth surfaces.

Surgical guide and method for guiding a therapy delivery device into the pterygopalatine fossa

Growing community of inventors

Westlake, OH, United States of America

Francis A Papay