Other

National Institute of Health and Medical Research

Peptide Immune Ligands

Assistance Publique-Hopitaux De Paris

Francine Connan

Jeannine Choppin

Estelle Ferries

Isabelle Bourgault Villada

Jean-G&eacute;rard Guillet

Polyepitopic peptides of E6 and E7 proteins of Human Papillomavirus, their production, and methods of treating pathologies in which a polyepitopic peptide of the E6 and E7 protein of Human Papillomavirus is recognized by the cellular immune system.

Polyepitopic protein fragments of the E6 and E7 proteins of HPV, their production and their use particularly in vaccination

Polyepitopic fragments of the E6 or E7 protein of HPV comprise a peptide sequence of about 15 to 30 amino acids. This peptide sequence contains amino acid sequences of at least 3 different epitopes binding stably to HLA molecules of identical or different type, when these epitopes are obtained by enzymatic degradation of the peptide sequence, particularly in the proteasome, such that at least 4 HLA molecules of different types bind to these epitopes. These 4 HLA molecules are selected from among those of types A1, A2, A3, A11, A24, A29, B7, B8, B18, B27, B35, B44, B51 and B62.

Polyepitopic proteinic fragments of the E6 and E7 HPV proteins, production and use thereof in vaccines

Growing community of inventors

Deuil la Barre, France

Francine Connan