Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Sorbonne Université

Université Paris Descartes

Universite Paris Cité

Université D'auvergne

Francine Acher

Robert Azerad

Jean-Philippe Pin

Alain Eschalier

Morgane Petit

Jérôme Busserolles

Cyril Goudet

Peter Dalko

David Ogden

Jean Philippe Pin

Delphine Rigault

Nicolas Pietrancosta

Isabelle Lemasson

Sara Cesarini

Sophie Gautron

Laetitia Chausset-Boissarie

Bruno Commare

Disclosed are organic cation transporters (OCTs) inhibitors of Formula (A), as well as their pharmaceutically acceptable tautomers, salts or solvates.  Also disclosed are pharmaceutical compositions including such OCTs inhibitor of Formula (A) and their use for treating and/or preventing mood-related disorders such as depressive disorders.

Selective organic cation transporters inhibitors for the treatment of depressive disorders

The invention relates to hypophosphorous acid derivatives of formula (I) wherein &#x2014;X is H or OH, &#x2014;R represents one or several radicals R-R, identical or different, two of R-Roptionally occupying the same position on the phenyl group, one to four of R-Rbeing H and the others being selected in the group comprising -0-(CH)&#x2014;COOH; &#x2014;S&#x2014;(CH)&#x2014;COOH; &#x2014;NH&#x2014;(CH)&#x2014;COOH; -0-(CH,R')&#x2014;COOH; &#x2014;O&#x2014;(CH)&#x2014;OH; OR&#x2032;, &#x2014;R&#x2032; being a C-Calkyl radical; &#x2014;OH; &#x2014;COOH; halogen, particularly &#x2014;F, &#x2014;CI, &#x2014;Br, &#x2014;I, &#x2014;CF; &#x2014;OCF; &#x2014;N0; &#x2014;CH&#x2550;CH&#x2014;COOH; &#x2014;(CH)&#x2014;COOH; O&#x2014;(CH)&#x2014;P0H; O&#x2014;(CF)&#x2014;P0H; O&#x2014;(CH)&#x2014;S0H; O&#x2014;(CH)&#x2014;CONHOH; O&#x2014;(CH)-tetrazol; O&#x2014;(CH)-hydroxyisoxazol&#x2014;n=1 to 5, preferably 1-3; said hypophosrous acid derivatives being diastereoisomers or enantiomers. 

Hypophosphorous acid derivatives having antihyperalgic activity and biological applications thereof

The present invention relates to multiphoton activable organic compounds responding to the following formula (I). The present invention also relates to a method of synthesizing the compounds of the invention, to an aqueous solution comprising at least one compound of the invention, and to their specific uses. The present invention also concerns a method of liberating organic ligands, said method involving the step of irradiating a compound according to the invention. 

Multiphoton activable quinoline derivatives, their preparation and their uses

Compounds consisting in particular of effectors of the central nervous system receptors sensitive excitatory amino acids, preparation and biological applications

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Vaucresson, France

Francine Acher