Procos Gmbh

Newron Pharmaceuticals S.p.a.

Francesco Velardi

Mirco Fornaroli

Patricia Salvati

Carla Caccia

Elena Barbanti

Tiziano Ruffilli

Luigi Bogogna

Diego Peverali

A process for obtaining therapeutically active 2-[4-(3- and 2-(fluorobenzyloxy)benzylamino]propanamides and their salts with pharmaceutically acceptable acids with high purity degree, in particular, with a content of dibenzyl derivatives impurities lower than 0.03%, preferably lower than 0.01% by weight. The process is carried out by submitting the Schiff bases intermediates 2-[4-(3- and 2-fluorobenzyloxy)benzylideneamino]propanamides to catalytic hydrogenation in the presence of a heterogeneous catalyst in a protic organic solvent.

Process for the production of 2-[4-(3- and 2-fluorobenzyloxy) benzylamino] propanamides

A process for the preparation of sodium divalproate by reacting valproic acid and sodium methoxide in an inert solvent, azeotropically removing the formed methanol.

Process for the preparation of sodium divalproate

Process for the preparation of 1-aminomethyl-1-cyclohexaneacetic acid

A process for the production and purification of gabapentin, i.e. 1-(aminomethyl)cyclohexyl-acetic acid, which comprises hydrolysis of 2-aza-spiro&lsqb;4.5&rsqb;decan-3-one with HCl, treatment of the resulting product and filtration with acetone, dissolution in water at isoelectric pH and crystallization or digestion in the hot in mixtures of diisopropyl ether with ethanol or methanol.

Process for the production of 1-(aminomethyl)-cyclohexyl-acetic acid in pure form

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Cameri, Italy

Francesco Velardi