Technische Universitaet Dresden

Dynabind Gmbh

Technische Universitát Dresden

Leibniz-institut Fur Polymerforschung Dresden E.v.

Tu Dresden

Francesco Reddavide

Yixin Zhang

Robert Wieduwild

Carsten Werner

Weilin Lin

Jana Herrmann

Mikhail Tsurkan

Helena De Andrade

Luca Mannocci

Meiying Cui

Helena Andrade

Stephan Heiden

Michael Thompson

The present invention relates to a method for the sensitive identification of high-affinity complexes made of two ligands () and one receptor (). A large number of different ligands () of a chemical library are hereby contacted with at least one receptor () in a solution. The ligands of the library have a single-strand DNA () or RNA with a base length of 2 to 10 bases or alternatively more than 10 bases. In addition, the solution is incubated for a specific period of time and complexes made of two ligands () and one receptor () are identified.

Method for identifying high-affinity complexes made of two ligands and one receptor, device for implementing the method and self-assembling chemical library for use in the method

In a method and arrangement for detecting binding events of molecules, at least one second molecule covalently bound to a ligand, and optionally bonded to a third molecule bound to a ligand, forms a specific non-covalent fond with a first molecule immobilised on a bioactive surface by a covalent bond, and binding events between an analyte molecule and the second-molecule bound ligand are detected by an analytical measuring method, wherein the specific non-covalent bond between the first and second molecules is breakable by supplying a buffer solution, and, hence, a specific ligand, or two, different specific ligands are made available on the bioactive surface in an easily reversible manner.

Method and arrangement for detecting binding events of molecules

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Dresden, Germany

Francesco Reddavide