Isf S.p.a.

I.s.f. Societa Per Azioni

Francesco Parravicini

Mario Pinza

Carlo Farina

Alberto Cerri

Luciano Dorigotti

A novel process for preparing alkoxyalkylidenehydrazinopyridazine derivatives which comprises reducing a novel alkoxytriphenylmethylazopyridazine derivative, removing the triphenylmethyl group and reacting with an aldehyde or ketone derivative. A specific compound produced by this process is 3-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-hydroxypropoxy]-6-isopropylid enehydrazinopyridazine.

Pyridazine derivatives

Process for preparing alkoxyalkylidenehydrazinopyridazine derivatives

A novel method of preparing ethyl{6-[ethyl-(2-hydroxypropyl)amino]-3-pyridazinyl}hydrazinecarboxylate is disclosed, wherein 7-chloro-3-methyl-4-oxo-4H-pyridazino[6,1-c][1,2,4]triazine is treated with ethyl-(2-hydroxypropyl)amine. The corresponding amino derivative is hydrolized in mild conditions and the hydrazino compound thus obtained is suitably acylated.

Process of making

Antihypertensive compounds comprising hydrazinopyridazine derivatives of the formula: ##STR1## wherein R is an alkyl radical containing from 1 to 4 carbon atoms or an alkyl radical having from 1 to 4 carbon atoms substituted with a hydroxy group and R.sub.1 is a hydrogen atom, an alkyl radical containing from 1 to 4 carbon atoms, a phenyl or 3-pyridyl group and their non-toxic pharmaceutically acceptable salts with inorganic or organic acids. Also pharmaceutical compositions containing the same.

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Milan, Italy

Francesco Parravicini